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Opinion|Videos|November 18, 2025

Treatment Sequencing in Later Lines of Therapy in HER2+ Metastatic Breast Cancer

Author(s)Neil M. Iyengar, MD, Kelly E. McCann, MD, PhD, Kamel Abou Hussein, MD

Panelists discuss how thoughtful sequencing of HER2-targeted agents maximizes benefit and extends survival in metastatic settings.

Episodes in this series

Experts featured in this series.

EP. 1 Background Information on Targeted Therapies in Breast Cancer

Experts featured in this series.

EP. 2 Clinical Trial Evidence for HER2-Targeted Therapies in Early Breast Cancer

Experts featured in this series.

EP. 3 The Role of ADCs in Different Subgroups

Experts featured in this series.

EP. 4 First-Line Treatment Regimens in Metastatic HER2+ Breast Cancer

Experts featured in this series.

EP. 5 Treatment Sequencing in Later Lines of Therapy in HER2+ Metastatic Breast Cancer

Experts featured in this series.

EP. 6 Additional Data with HER2-Targeted Agents in Metastatic Breast Cancer

Experts featured in this series.

EP. 7 Treatment of HER2-Low and Future Therapies in Metastatic Breast Cancer

Experts featured in this series.

EP. 8 Disease State Information on TNBC

Experts featured in this series.

EP. 9 Exciting New Data for TNBC Therapies

Experts featured in this series.

EP. 10 Unmet Needs and Future Outlook for HER2-Targeted Therapies

Panelists discuss how:
Ttherapeutic sequencing in advanced HER2-positive disease has become increasingly complex. The experts review data supporting novel ADCsantibody-drug conjugates, TKIstyrosine kinase inhibitors, and combination regimens used beyond first-line therapy. They emphasize strategic sequencing to overcome resistance, preserve performance status, and extend survival. The conversation also covers real-world barriers such as treatment accessibility, toxicity management, and quality-of-life considerations when transitioning between lines.

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