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Opinion|Videos|July 2, 2024

Dr Xu Reviews Data from the CLEAR Trial and Recent Analyses at ASCO 2024 - Lenvatinib + Pembrolizumab in Frontline Advanced RCC

Author(s)Pedro Barata, MD, MSc, Martin H. Voss, MD, Elizabeth Wulff-Burchfield, MD

Wenxin (Vincent) Xu, MD, reviews recent analyses from the CLEAR study, which evaluated the combination of lenvatinib and pembrolizumab as a frontline treatment for advanced renal cell carcinoma (RCC).

Episodes in this series

4 KOLs are featured in this series

EP. 1 Treatment Selection in the Frontline Setting of Advanced Clear Cell RCC

4 KOLs are featured in this series

EP. 2 Dr Wulff-Burchfield Reviews CheckMate 214 and CheckMate 9ER

4 KOLs are featured in this series

EP. 3 Dr Xu Reviews Data from the CLEAR Trial and Recent Analyses at ASCO 2024 - Lenvatinib + Pembrolizumab in Frontline Advanced RCC

4 KOLs are featured in this series

EP. 4 Dr Voss Shares Highlights from the COSMIC-313 and LITESPARK-024 Trials

4 KOLs are featured in this series

EP. 5 Exciting Data and Trials in Progress from ASCO 2024

4 KOLs are featured in this series

EP. 6 Ongoing RCC Clinical Trials that may Impact Practice

4 KOLs are featured in this series

EP. 7 Dr Xu Provides Clinical Perspective on the CONTACT-03 Trial Outcomes

4 KOLs are featured in this series

EP. 8 Dr Voss Application of Updated KEYNOTE-564 Data

4 KOLs are featured in this series

EP. 9 Guiding Sequencing & Finding a Contemporary Regimen/ Approach to Treatment Post-Checkpoint Inhibition

4 KOLs are featured in this series

EP. 10 World Health Organization (WHO) Classification Updates for Papillary RCC

4 KOLs are featured in this series

EP. 11 Additional Forward-Looking Data and Studies Beyond Frontline Therapy in RCC

4 KOLs are featured in this series

EP. 12 The Role of Chemotherapy in nccRCC Treatment

4 KOLs are featured in this series

EP. 13 Select Ongoing Trials for nccRCC and Impact on the Treatment Landscape

4 KOLs are featured in this series

EP. 14 Final Thoughts/Looking Forward

Please discuss recent analyses from the CLEAR study, evaluating lenvatinib + pembro in frontline advanced RCC.
1. Efficacy by baseline tumor size (Grunwald, et al. ASCO GU 2024. Abstract 364)
2. Biomarker analysis (Motzer et al. ASCO 2024 Abstract 4504)
3. Network meta-analysis– len + pembro vs other 1L treatments in advanced RCC (Grunwald, et al. ASCO GU 2024. Abstract 482)

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