
Opinion|Videos|July 29, 2024
Guiding Sequencing & Finding a Contemporary Regimen/ Approach to Treatment Post-Checkpoint Inhibition
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- Please briefly mention the recent retrospective findings with cabo post-len + pembro – (
Haro-Silerio, et al. ASCO GU 2024. Abstract 433 ) = How do you approach treatment post-IO? - Please highlight recent data from the LITESPARK-011 trial(NCT04586231) evaluating belzutifan + lenvatinib vs cabozantinib in advanced RCC after anti-PD-L1 therapy (
Motzer, et al. Future Med, 2023
a. Please also briefly mention the significance of recent data from the phase 3 LITESPARK-005 trial (NCT04195750) assessing belzutifan versus everolimus in previously treated advanced RCC patients
i. Safety and Efficacy – (
ii. Patient reported outcomes – (
b.How does belzutifan fit into your treatment paradigm?
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Related to this article

Here is your cheat sheet to all therapeutic options that were cleared by the FDA in September 2026 spanning tumor types.

The FDA approved tucatinib plus trastuzumab and pertuzumab as maintenance for advanced HER2-positive breast cancer after induction.

The c-Met–directed ADC was designated for EGFR wild-type nonsquamous NSCLC after platinum chemotherapy and anti–PD-(L)1 therapy.

Dana-Farber’s Xin Gu, PhD, and Nicholas Polizzi, PhD, received NIH New Innovator Awards for high-risk, high-reward research.

The c-Met–directed ADC-based combination was designated for mCRC previously treated with fluoropyrimidine, irinotecan, oxaliplatin, and anti-VEGF therapy.

Pooled data from 3 randomized trials showed ropeginterferon alfa-2b improved responses vs phlebotomy alone but not vs hydroxyurea in polycythemia vera.
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