
Opinion|Videos|July 8, 2024
Exciting Data and Trials in Progress from ASCO 2024
Elizabeth Wulff-Burchfield, MD, facilitates a conversation about several clinical trials, such as STELLAR-001 and KEYNOTE-426, which investigate various treatment approaches for renal cell carcinoma (RCC).
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Episodes in this series

- Please briefly discuss recent findings from ongoing trials and novel treatment strategies.
- STELLAR-001 single-agent zanzalintinib biomarker analysis (Pal et al, ASCO 2024)
- KEYNOTE-426 Phase 3 pembro + axitinib biomarker analysis (Rini et al., ASCO 2024 Abstract 4505)
- Phase 3 trial len + pembro + belzutifan/quavonlima (Choueiri, ASCO GU 2022: Abstract TPS399)
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Here is your cheat sheet to all therapeutic options that were cleared by the FDA in September 2026 spanning tumor types.

The FDA approved tucatinib plus trastuzumab and pertuzumab as maintenance for advanced HER2-positive breast cancer after induction.

The c-Met–directed ADC was designated for EGFR wild-type nonsquamous NSCLC after platinum chemotherapy and anti–PD-(L)1 therapy.

Dana-Farber’s Xin Gu, PhD, and Nicholas Polizzi, PhD, received NIH New Innovator Awards for high-risk, high-reward research.

The c-Met–directed ADC-based combination was designated for mCRC previously treated with fluoropyrimidine, irinotecan, oxaliplatin, and anti-VEGF therapy.

Pooled data from 3 randomized trials showed ropeginterferon alfa-2b improved responses vs phlebotomy alone but not vs hydroxyurea in polycythemia vera.
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