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Opinion|Videos|February 17, 2025

Emerging Agents and Future Strategies in Relapsed/Refractory CLL

Author(s)Carsten Niemann, MD, PhD, Arnon Kater, MD, PhD, Othman Al-Sawaf, MD

Panelists discuss the role of non-covalent BTKis in this setting and available supporting data (high level).

Episodes in this series

EP. 1 Recent Guideline Updates in the Frontline Management of CLL

EP. 1 Recent Guideline Updates in the Frontline Management of CLL

EP. 2 Tailoring Treatment Approaches for Fit vs Unfit CLL Patients

EP. 2 Tailoring Treatment Approaches for Fit vs Unfit CLL Patients

EP. 3 Implications of ESMO Guidelines for IGHV-Mutated vs Unmutated CLL Patients

EP. 3 Implications of ESMO Guidelines for IGHV-Mutated vs Unmutated CLL Patients

EP. 4 Time-Limited Therapy with Venetoclax-Obinutuzumab: Rationale and Data

EP. 4 Time-Limited Therapy with Venetoclax-Obinutuzumab: Rationale and Data

EP. 5 Clinical Insights and Real-World Evidence

EP. 5 Clinical Insights and Real-World Evidence

EP. 6 Doublet Therapy With Venetoclax-Ibrutinib: Data and Guidelines

EP. 6 Doublet Therapy With Venetoclax-Ibrutinib: Data and Guidelines

EP. 7 Comparing Venetoclax-Ibrutinib, Venetoclax-Obinutuzumab, and BTKi Options

EP. 7 Comparing Venetoclax-Ibrutinib, Venetoclax-Obinutuzumab, and BTKi Options

EP. 8 Managing CLL with TP53 Mutation or del(17p): Guidelines and Strategies

EP. 8 Managing CLL with TP53 Mutation or del(17p): Guidelines and Strategies

EP. 9 Exploring Novel BCL2i and BTKi Combinations in Frontline CLL Therapy

EP. 9 Exploring Novel BCL2i and BTKi Combinations in Frontline CLL Therapy

EP. 10 Relapse After Venetoclax-Based Therapy: Early vs Late Management

EP. 10 Relapse After Venetoclax-Based Therapy: Early vs Late Management

EP. 11 Progression on BTK Inhibitors: Treatment Options and Considerations

EP. 11 Progression on BTK Inhibitors: Treatment Options and Considerations

$EP. 12 Emerging Agents and Future Strategies in Relapsed/Refractory CLL$

EP. 12 Emerging Agents and Future Strategies in Relapsed/Refractory CLL

EP. 13 Reflections and Future Directions in CLL Management

EP. 13 Reflections and Future Directions in CLL Management

Video content above is prompted by the following:

Briefly comment on the role of non-covalent BTKis in this setting and available supporting data (high level). BRUIN CLL-321 – Sharman JP, et al. ASH 2024. Abs 886

Relapsed/Refractory CLL with TP53 mutation or del(17p)

Briefly review recent ESMO guideline updates for managing patients with R/R CLL and TP53 mutations or del(17p).
- What is your preferred treatment approach in this setting?
- What factors/data do you use to guide your treatment decision in this setting?

Other Treatment Strategies in the 3L in and Beyond

Briefly comment on the role of CAR T therapy in managing R/R CLL and available supporting data.
- TRANSCEND CLL-004 –Siddiqi T, et al. ASH 2024. Abs 4633
- In what scenarios do you see a role for this approach, and which patients would you consider for this treatment?

Module III: Looking Ahead: Future Perspective in CLL (15 min)

Briefly share your perspective/insights on emerging novel agents in R/R CLL.
- Combination approaches with venetoclax
  - Venetoclax + acalabrutinib
  - Venetoclax + pirtobrutinib
- BTKi degraders:
  - BGB-16673 - Parrando, et al EHA S157. Abs S157 
  - NX-5948 - Shah NN, et al. ASH 2024. Abs 884
-  Bispecific antibodies:
  - Epcoritamab - Danilov A, et al. ASH 2024. Abs 883
- 2^nd gen BCL2 inhibitors:
  - Sonrotoclax - Soumerai JD, et al. ASH 2024. Abs 1012
  - Lisaftoclax - Davids MS, et al. ASH 2024. Abs 4614

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