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Opinion|Videos|February 17, 2025

Reflections and Future Directions in CLL Management

Author(s)Carsten Niemann, MD, PhD, Arnon Kater, MD, PhD, Othman Al-Sawaf, MD

Panelists comment on the increasing preference for fixed-duration therapy over treatment until progression, as reflected in recent guideline updates.

Episodes in this series

EP. 1 Recent Guideline Updates in the Frontline Management of CLL

EP. 1 Recent Guideline Updates in the Frontline Management of CLL

EP. 2 Tailoring Treatment Approaches for Fit vs Unfit CLL Patients

EP. 2 Tailoring Treatment Approaches for Fit vs Unfit CLL Patients

EP. 3 Implications of ESMO Guidelines for IGHV-Mutated vs Unmutated CLL Patients

EP. 3 Implications of ESMO Guidelines for IGHV-Mutated vs Unmutated CLL Patients

EP. 4 Time-Limited Therapy with Venetoclax-Obinutuzumab: Rationale and Data

EP. 4 Time-Limited Therapy with Venetoclax-Obinutuzumab: Rationale and Data

EP. 5 Clinical Insights and Real-World Evidence

EP. 5 Clinical Insights and Real-World Evidence

EP. 6 Doublet Therapy With Venetoclax-Ibrutinib: Data and Guidelines

EP. 6 Doublet Therapy With Venetoclax-Ibrutinib: Data and Guidelines

EP. 7 Comparing Venetoclax-Ibrutinib, Venetoclax-Obinutuzumab, and BTKi Options

EP. 7 Comparing Venetoclax-Ibrutinib, Venetoclax-Obinutuzumab, and BTKi Options

EP. 8 Managing CLL with TP53 Mutation or del(17p): Guidelines and Strategies

EP. 8 Managing CLL with TP53 Mutation or del(17p): Guidelines and Strategies

EP. 9 Exploring Novel BCL2i and BTKi Combinations in Frontline CLL Therapy

EP. 9 Exploring Novel BCL2i and BTKi Combinations in Frontline CLL Therapy

EP. 10 Relapse After Venetoclax-Based Therapy: Early vs Late Management

EP. 10 Relapse After Venetoclax-Based Therapy: Early vs Late Management

EP. 11 Progression on BTK Inhibitors: Treatment Options and Considerations

EP. 11 Progression on BTK Inhibitors: Treatment Options and Considerations

$EP. 12 Emerging Agents and Future Strategies in Relapsed/Refractory CLL$

EP. 12 Emerging Agents and Future Strategies in Relapsed/Refractory CLL

EP. 13 Reflections and Future Directions in CLL Management

EP. 13 Reflections and Future Directions in CLL Management

Video content above is prompted by the following:

Briefly comment on the increasing preference for fixed-duration therapy over treatment until progression, as reflected in recent guideline updates:
- How do you view the balance between fixed-duration and treat-to-progression approaches?
- How might strategies continue to evolve, and what implications could it have for future treatment practices?

Before we wrap up, I’d like to hear your final thoughts and reflections on the strides we made throughout 2024—including new/exciting data presented at ASH 2024.
Let’s consider what opportunities/what we are looking forward to ahead in 2025. Points to consider:
- What accomplishments in CLL are you most proud of?
- Which developments stand out as pivotal in shaping clinical practice?
- What are you most excited about in 2025?
- What areas are primed for significant progress? What do you hope to achieve in the coming year?

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