
Opinion|Videos|February 17, 2025
Reflections and Future Directions in CLL Management
Panelists comment on the increasing preference for fixed-duration therapy over treatment until progression, as reflected in recent guideline updates.
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Episodes in this series

Video content above is prompted by the following:
- Briefly comment on the increasing preference for fixed-duration therapy over treatment until progression, as reflected in recent guideline updates:
- How do you view the balance between fixed-duration and treat-to-progression approaches?
- How might strategies continue to evolve, and what implications could it have for future treatment practices?
- Before we wrap up, I’d like to hear your final thoughts and reflections on the strides we made throughout 2024—including new/exciting data presented at ASH 2024.
Let’s consider what opportunities/what we are looking forward to ahead in 2025. Points to consider:- What accomplishments in CLL are you most proud of?
- Which developments stand out as pivotal in shaping clinical practice?
- What are you most excited about in 2025?
- What areas are primed for significant progress? What do you hope to achieve in the coming year?
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The FDA approved pirtobrutinib for untreated chronic lymphocytic leukemia, granted priority review to elinzanetant for breast cancer hot flashes, and more.

The FDA has approved pirtobrutinib for the treatment of adult patients with previously untreated CLL or SLL harboring no known 17p deletion.
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