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Opinion|Videos|February 3, 2025

Managing CLL with TP53 Mutation or del(17p): Guidelines and Strategies

Author(s)Carsten Niemann, MD, PhD, Arnon Kater, MD, PhD, Othman Al-Sawaf, MD

Panelists review recent ESMO guideline updates for the frontline management of patients with CLL and a TP53 or del(17p) mutation.

Episodes in this series

EP. 1 Recent Guideline Updates in the Frontline Management of CLL

EP. 1 Recent Guideline Updates in the Frontline Management of CLL

EP. 2 Tailoring Treatment Approaches for Fit vs Unfit CLL Patients

EP. 2 Tailoring Treatment Approaches for Fit vs Unfit CLL Patients

EP. 3 Implications of ESMO Guidelines for IGHV-Mutated vs Unmutated CLL Patients

EP. 3 Implications of ESMO Guidelines for IGHV-Mutated vs Unmutated CLL Patients

EP. 4 Time-Limited Therapy with Venetoclax-Obinutuzumab: Rationale and Data

EP. 4 Time-Limited Therapy with Venetoclax-Obinutuzumab: Rationale and Data

EP. 5 Clinical Insights and Real-World Evidence

EP. 5 Clinical Insights and Real-World Evidence

EP. 6 Doublet Therapy With Venetoclax-Ibrutinib: Data and Guidelines

EP. 6 Doublet Therapy With Venetoclax-Ibrutinib: Data and Guidelines

EP. 7 Comparing Venetoclax-Ibrutinib, Venetoclax-Obinutuzumab, and BTKi Options

EP. 7 Comparing Venetoclax-Ibrutinib, Venetoclax-Obinutuzumab, and BTKi Options

EP. 8 Managing CLL with TP53 Mutation or del(17p): Guidelines and Strategies

EP. 8 Managing CLL with TP53 Mutation or del(17p): Guidelines and Strategies

EP. 9 Exploring Novel BCL2i and BTKi Combinations in Frontline CLL Therapy

EP. 9 Exploring Novel BCL2i and BTKi Combinations in Frontline CLL Therapy

EP. 10 Relapse After Venetoclax-Based Therapy: Early vs Late Management

EP. 10 Relapse After Venetoclax-Based Therapy: Early vs Late Management

EP. 11 Progression on BTK Inhibitors: Treatment Options and Considerations

EP. 11 Progression on BTK Inhibitors: Treatment Options and Considerations

$EP. 12 Emerging Agents and Future Strategies in Relapsed/Refractory CLL$

EP. 12 Emerging Agents and Future Strategies in Relapsed/Refractory CLL

EP. 13 Reflections and Future Directions in CLL Management

EP. 13 Reflections and Future Directions in CLL Management

Video content above is prompted by the following:

Briefly review recent ESMO guideline updates for the frontline management of patients with CLL and a TP53 or del(17p) mutation and discuss associated implications. (ESMO CLL Guideline Update 2024)
- How does the presence of TP53 or del(17p) mutations alter your overall treatment approach?
- How does the role of time-limited vs continuous BTKi therapy in the 1L setting differ in this patient population?
Briefly comment on the underlying rationale and data supporting BTKi therapy as a preferred approach in this setting.
- SEQUOIA – Shadman M, et al. ASH 2024. Abs 3249
- ELEVATE-TN – Sharman JP, et al. ASH 2023. Abs 642

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