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Opinion|Videos|February 10, 2025

Relapse After Venetoclax-Based Therapy: Early vs Late Management

Author(s)Carsten Niemann, MD, PhD, Arnon Kater, MD, PhD, Othman Al-Sawaf, MD

Panelists review recent ESMO guideline updates for managing early relapse after venetoclax-based time-limited therapy, managing relapse after chemoimmunotherapy or late relapse after venetoclax-based time-limited therapy and defining early versus late relapse.

Episodes in this series

EP. 1 Recent Guideline Updates in the Frontline Management of CLL

EP. 1 Recent Guideline Updates in the Frontline Management of CLL

EP. 2 Tailoring Treatment Approaches for Fit vs Unfit CLL Patients

EP. 2 Tailoring Treatment Approaches for Fit vs Unfit CLL Patients

EP. 3 Implications of ESMO Guidelines for IGHV-Mutated vs Unmutated CLL Patients

EP. 3 Implications of ESMO Guidelines for IGHV-Mutated vs Unmutated CLL Patients

EP. 4 Time-Limited Therapy with Venetoclax-Obinutuzumab: Rationale and Data

EP. 4 Time-Limited Therapy with Venetoclax-Obinutuzumab: Rationale and Data

EP. 5 Clinical Insights and Real-World Evidence

EP. 5 Clinical Insights and Real-World Evidence

EP. 6 Doublet Therapy With Venetoclax-Ibrutinib: Data and Guidelines

EP. 6 Doublet Therapy With Venetoclax-Ibrutinib: Data and Guidelines

EP. 7 Comparing Venetoclax-Ibrutinib, Venetoclax-Obinutuzumab, and BTKi Options

EP. 7 Comparing Venetoclax-Ibrutinib, Venetoclax-Obinutuzumab, and BTKi Options

EP. 8 Managing CLL with TP53 Mutation or del(17p): Guidelines and Strategies

EP. 8 Managing CLL with TP53 Mutation or del(17p): Guidelines and Strategies

EP. 9 Exploring Novel BCL2i and BTKi Combinations in Frontline CLL Therapy

EP. 9 Exploring Novel BCL2i and BTKi Combinations in Frontline CLL Therapy

EP. 10 Relapse After Venetoclax-Based Therapy: Early vs Late Management

EP. 10 Relapse After Venetoclax-Based Therapy: Early vs Late Management

EP. 11 Progression on BTK Inhibitors: Treatment Options and Considerations

EP. 11 Progression on BTK Inhibitors: Treatment Options and Considerations

$EP. 12 Emerging Agents and Future Strategies in Relapsed/Refractory CLL$

EP. 12 Emerging Agents and Future Strategies in Relapsed/Refractory CLL

EP. 13 Reflections and Future Directions in CLL Management

EP. 13 Reflections and Future Directions in CLL Management

Video content above is prompted by the following:

Briefly review recent ESMO guideline updates for managing early relapse after venetoclax-based time-limited therapy. (ESMO CLL Guideline Update 2024)
Briefly comment on the underlying rationale and supporting data (high level) for continuous BTKi therapy in this setting.
- ALPINE – Brown, et al. ASH 2023. Abstract 202
- ELEVATE-RR– Seymour, et al. Blood. 2023
- How do you incorporate these data and recommendations into your treatment approach?

Late Relapse After 1L Venetoclax

Briefly review recent ESMO guideline updates for managing relapse after chemoimmunotherapy or late relapse after venetoclax-based time-limited therapy.
- How do you define early versus late relapse, and how does your treatment approach differ for each following venetoclax-based time-limited therapy?
- At what point do you consider retreatment with venetoclax?

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