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Opinion|Videos|January 6, 2025

Recent Guideline Updates in the Frontline Management of CLL

Author(s)Carsten Niemann, MD, PhD, Arnon Kater, MD, PhD, Othman Al-Sawaf, MD

Dr Niemann provides an overview of the evolving treatment landscape of CLL.

Episodes in this series

EP. 1 Recent Guideline Updates in the Frontline Management of CLL

EP. 1 Recent Guideline Updates in the Frontline Management of CLL

EP. 2 Tailoring Treatment Approaches for Fit vs Unfit CLL Patients

EP. 2 Tailoring Treatment Approaches for Fit vs Unfit CLL Patients

EP. 3 Implications of ESMO Guidelines for IGHV-Mutated vs Unmutated CLL Patients

EP. 3 Implications of ESMO Guidelines for IGHV-Mutated vs Unmutated CLL Patients

EP. 4 Time-Limited Therapy with Venetoclax-Obinutuzumab: Rationale and Data

EP. 4 Time-Limited Therapy with Venetoclax-Obinutuzumab: Rationale and Data

EP. 5 Clinical Insights and Real-World Evidence

EP. 5 Clinical Insights and Real-World Evidence

EP. 6 Doublet Therapy With Venetoclax-Ibrutinib: Data and Guidelines

EP. 6 Doublet Therapy With Venetoclax-Ibrutinib: Data and Guidelines

EP. 7 Comparing Venetoclax-Ibrutinib, Venetoclax-Obinutuzumab, and BTKi Options

EP. 7 Comparing Venetoclax-Ibrutinib, Venetoclax-Obinutuzumab, and BTKi Options

EP. 8 Managing CLL with TP53 Mutation or del(17p): Guidelines and Strategies

EP. 8 Managing CLL with TP53 Mutation or del(17p): Guidelines and Strategies

EP. 9 Exploring Novel BCL2i and BTKi Combinations in Frontline CLL Therapy

EP. 9 Exploring Novel BCL2i and BTKi Combinations in Frontline CLL Therapy

EP. 10 Relapse After Venetoclax-Based Therapy: Early vs Late Management

EP. 10 Relapse After Venetoclax-Based Therapy: Early vs Late Management

EP. 11 Progression on BTK Inhibitors: Treatment Options and Considerations

EP. 11 Progression on BTK Inhibitors: Treatment Options and Considerations

$EP. 12 Emerging Agents and Future Strategies in Relapsed/Refractory CLL$

EP. 12 Emerging Agents and Future Strategies in Relapsed/Refractory CLL

EP. 13 Reflections and Future Directions in CLL Management

EP. 13 Reflections and Future Directions in CLL Management

Video content above is prompted by the following:

Provide a brief review of the evolving treatment landscape for newly diagnosed CLL.
- Available therapy options (time-limited vs continuous).
- Preference for targeted therapy approaches over conventional chemotherapy.
- Key challenges and unmet needs in the 1L setting.

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