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Opinion|Videos|February 26, 2025

Expert Insights: Challenges With ctDNA Testing in BTC

Author(s)Shubham Pant, MD, MBBS, Haley Ellis, MD , Amit Mahipal, MD

Panelists discuss how circulating tumor DNA (ctDNA) testing in biliary tract cancer (BTC) presents unique technical and interpretative challenges, including considerations around sensitivity, timing of collection, and clinical validation of results.

Episodes in this series

4 experts are featured in this series.

EP. 1 Guiding Patients Through Advanced BTC Prognosis and Expectations

4 experts are featured in this series.

EP. 2 The Importance of Early Biomarker Testing in Managing Advanced BTC

4 experts are featured in this series.

EP. 3 Biomarker Testing in BTC: Approaches and Practices Across Academic and Community Clinicians

4 experts are featured in this series.

EP. 4 Expert Insights: Challenges With ctDNA Testing in BTC

4 experts are featured in this series.

EP. 5 Landmark Trials in First-Line Treatment Landscape for Advanced BTC: Expert Insights from TOPAZ-1 and KEYNOTE-966 Trials

4 experts are featured in this series.

EP. 6 Applying Data to Clinical Practice: Immunotherapy in the First-Line Treatment Setting in Advanced BTC

4 experts are featured in this series.

EP. 7 Understanding HER2 Testing in BTC: Detection and Clinical Approaches

4 experts are featured in this series.

EP. 8 Expert Perspectives From DESTINY-PanTumor 02 and Real-World Experience with Trastuzumab Deruxtecan in HER2-Positive BTC

4 experts are featured in this series.

EP. 9 New Approvals in HER2-Positive BTC: Zanidatamab - Key Findings from HERIZON-BTC-01 Study

4 experts are featured in this series.

EP. 10 Expert Perspectives in HER2-Positive BTC: Trastuzumab With Pertuzumab or Tucatinib From MyPathway and SGNTUC-019 Trials

4 experts are featured in this series.

EP. 11 Clinical Insights: Incorporating Zanidatamab and Other HER2-Targeted Agents Into the Real-World Practice in Advanced BTC

4 experts are featured in this series.

EP. 12 Future Perspectives and Unmet Needs in HER2-Positive Advanced BTC Treatment

4 experts are featured in this series.

EP. 13 Key Takeaways From ASCO GI 2025: Exciting Updates on BTC

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