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Opinion|Videos|March 5, 2025

Landmark Trials in First-Line Treatment Landscape for Advanced BTC: Expert Insights from TOPAZ-1 and KEYNOTE-966 Trials

Author(s)Shubham Pant, MD, MBBS, Haley Ellis, MD , Amit Mahipal, MD

Panelists discuss how the practice-changing TOPAZ-1 trial established durvalumab plus gemcitabine/cisplatin as a first-line standard for advanced biliary tract cancer (BTC) while exploring key clinical factors that influence the choice between durvalumab and pembrolizumab-based combinations following the KEYNOTE-966 results.

Episodes in this series

4 experts are featured in this series.

EP. 1 Guiding Patients Through Advanced BTC Prognosis and Expectations

4 experts are featured in this series.

EP. 2 The Importance of Early Biomarker Testing in Managing Advanced BTC

4 experts are featured in this series.

EP. 3 Biomarker Testing in BTC: Approaches and Practices Across Academic and Community Clinicians

4 experts are featured in this series.

EP. 4 Expert Insights: Challenges With ctDNA Testing in BTC

4 experts are featured in this series.

EP. 5 Landmark Trials in First-Line Treatment Landscape for Advanced BTC: Expert Insights from TOPAZ-1 and KEYNOTE-966 Trials

4 experts are featured in this series.

EP. 6 Applying Data to Clinical Practice: Immunotherapy in the First-Line Treatment Setting in Advanced BTC

4 experts are featured in this series.

EP. 7 Understanding HER2 Testing in BTC: Detection and Clinical Approaches

4 experts are featured in this series.

EP. 8 Expert Perspectives From DESTINY-PanTumor 02 and Real-World Experience with Trastuzumab Deruxtecan in HER2-Positive BTC

4 experts are featured in this series.

EP. 9 New Approvals in HER2-Positive BTC: Zanidatamab - Key Findings from HERIZON-BTC-01 Study

4 experts are featured in this series.

EP. 10 Expert Perspectives in HER2-Positive BTC: Trastuzumab With Pertuzumab or Tucatinib From MyPathway and SGNTUC-019 Trials

4 experts are featured in this series.

EP. 11 Clinical Insights: Incorporating Zanidatamab and Other HER2-Targeted Agents Into the Real-World Practice in Advanced BTC

4 experts are featured in this series.

EP. 12 Future Perspectives and Unmet Needs in HER2-Positive Advanced BTC Treatment

4 experts are featured in this series.

EP. 13 Key Takeaways From ASCO GI 2025: Exciting Updates on BTC

Video content above is prompted by the following:

Moving into first-line treatment options for advanced BTC, can you briefly describe the TOPAZ-1 trial and how these results impacted your clinical practice?
Another checkpoint inhibitor combination is with pembrolizumab from the KEYNOTE-966 trial. What factors do you consider when selecting between a durvalumab vs pembrolizumab combination?

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