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Opinion|Videos|July 2, 2024

Exploring Dato-DXd Combinations as First-Line Therapy for Advanced NSCLC

Author(s)Mark A. Socinski, MD, Helena A. Yu, MD, Zosia Piotrowska, MD, MHS

Julia Rotow, MD, explores the rationale, study design, and primary endpoints of the AVANZAR trial, which investigated the combination of datopotamab deruxtecan (Dato-DXd), durvalumab, and carboplatin as a first-line treatment for patients with advanced non-small cell lung cancer lacking actionable mutations, and discusses the patient population most likely to benefit from this drug combination.

Episodes in this series

5 KOLs are featured in this peer exchange

EP. 1 Treatment Strategies for NSCLC with Non-Actionable Mutations

5 KOLs are featured in this peer exchange

EP. 2 Role of Antibody-Drug Conjugates in NSCLC Treatment: Insights from EVOKE-02

5 KOLs are featured in this peer exchange

EP. 3 Exploring the TROPION-Lung04 Study

5 KOLs are featured in this peer exchange

EP. 4 Exploring Dato-DXd Combinations as First-Line Therapy for Advanced NSCLC

5 KOLs are featured in this peer exchange

EP. 5 Navigating Between ADCs in NSCLC

5 KOLs are featured in this peer exchange

EP. 6 Advancing Treatment for EGFR-Mutant Advanced NSCLC: Lessons from FLAURA2

5 KOLs are featured in this peer exchange

EP. 7 Osimertinib Monotherapy vs. Combination Therapy: Patient Selection in EGFR-Mutant Advanced NSCLC

5 KOLs are featured in this peer exchange

EP. 8 MARIPOSA Study Insights

5 KOLs are featured in this peer exchange

EP. 9 Optimizing Therapy Selection in EGFR Mutant NSCLC

5 KOLs are featured in this peer exchange

EP. 10 ASCO 2024 Updates: Novel Approaches in NSCLC Therapy

5 KOLs are featured in this peer exchange

EP. 11 Overview of TROP2 & Potential Role of TROP2-Directed ADCs in NSCLC

5 KOLs are featured in this peer exchange

EP. 12 Key Takeaways from TROPION Trials: Implications for NSCLC Treatment Landscape

5 KOLs are featured in this series.

EP. 13 Targeting of HER3: Insights from HERTHENA-Lung01

5 KOLs featured in this series

EP. 14 Challenges and Learnings from EVOKE-01

5 KOLs featured in this series

EP. 15 Key ADC Studies at ASCO 2024

5 KOLs featured in this series

EP. 16 Mitigating Toxicities of Dato-DXd, Sacituzumab Govitecan, and HER3-DXd

5 KOLs featured in this series

EP. 17 Patient Selection and Sequencing of NSCLC ADCs

Please discuss the rationale, study design, and key endpoints for the AVANZAR (Aggarwal et al. WCLC 2023) trial evaluating Dato-DXd + durvalumab and carboplatin for 1L treatment of patients with advanced NSCLC without actionable mutations.
1. What is the rationale for this treatment approach?
2. What data do you anticipate and how may findings impact the current/future treatment landscape?
3. In which patients would this treatment strategy most appropriate/beneficial?

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