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Opinion|Videos|August 5, 2024

Targeting of HER3: Insights from HERTHENA-Lung01

Author(s)Mark A. Socinski, MD, Helena A. Yu, MD, Zosia Piotrowska, MD, MHS

Helena A. Yu, MD, initiates a discussion on the role of HER3 in the development of resistance to EGFR-targeted therapies. She also examines the HERTHENA-Lung01 study and analyzes the emerging data from this trial.

Episodes in this series

5 KOLs are featured in this peer exchange

EP. 1 Treatment Strategies for NSCLC with Non-Actionable Mutations

5 KOLs are featured in this peer exchange

EP. 2 Role of Antibody-Drug Conjugates in NSCLC Treatment: Insights from EVOKE-02

5 KOLs are featured in this peer exchange

EP. 3 Exploring the TROPION-Lung04 Study

5 KOLs are featured in this peer exchange

EP. 4 Exploring Dato-DXd Combinations as First-Line Therapy for Advanced NSCLC

5 KOLs are featured in this peer exchange

EP. 5 Navigating Between ADCs in NSCLC

5 KOLs are featured in this peer exchange

EP. 6 Advancing Treatment for EGFR-Mutant Advanced NSCLC: Lessons from FLAURA2

5 KOLs are featured in this peer exchange

EP. 7 Osimertinib Monotherapy vs. Combination Therapy: Patient Selection in EGFR-Mutant Advanced NSCLC

5 KOLs are featured in this peer exchange

EP. 8 MARIPOSA Study Insights

5 KOLs are featured in this peer exchange

EP. 9 Optimizing Therapy Selection in EGFR Mutant NSCLC

5 KOLs are featured in this peer exchange

EP. 10 ASCO 2024 Updates: Novel Approaches in NSCLC Therapy

5 KOLs are featured in this peer exchange

EP. 11 Overview of TROP2 & Potential Role of TROP2-Directed ADCs in NSCLC

5 KOLs are featured in this peer exchange

EP. 12 Key Takeaways from TROPION Trials: Implications for NSCLC Treatment Landscape

5 KOLs are featured in this series.

EP. 13 Targeting of HER3: Insights from HERTHENA-Lung01

5 KOLs featured in this series

EP. 14 Challenges and Learnings from EVOKE-01

5 KOLs featured in this series

EP. 15 Key ADC Studies at ASCO 2024

5 KOLs featured in this series

EP. 16 Mitigating Toxicities of Dato-DXd, Sacituzumab Govitecan, and HER3-DXd

5 KOLs featured in this series

EP. 17 Patient Selection and Sequencing of NSCLC ADCs

Please discuss the role of HER3 in the development of resistance to EGFR targeted therapies. (Manickavasagar, et al. Lung Cancer Mang, 2021; Engelman, et al. Science, 2007)
- Describe the rationale for targeting HER3 in patients with EGFR TKI resistance.
- What have data shown with treatment strategies using dual targeting of HER3 and EGFR?

Please review the rationale and study design for HERTHENA-Lung01 and discuss emerging study data and its implications on the treatment landscape. (Goto, et al. WCLC 2023. Abstract OA05.03; Johnson, et al. ESMO 2023. Abstract 1319MO)
- Briefly outline the study design and key endpoints. What are your perceptions around the brain mets data presented at ESMO this past year?
- What are some key takeaways from safety data?
- What implications may these findings have on clinical practice?

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