Opinion|Videos|August 5, 2024
Targeting of HER3: Insights from HERTHENA-Lung01
Helena A. Yu, MD, initiates a discussion on the role of HER3 in the development of resistance to EGFR-targeted therapies. She also examines the HERTHENA-Lung01 study and analyzes the emerging data from this trial.
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Episodes in this series
- Please discuss the role of HER3 in the development of resistance to EGFR targeted therapies. (
Manickavasagar, et al. Lung Cancer Mang, 2021 ;Engelman, et al. Science, 2007 )- Describe the rationale for targeting HER3 in patients with EGFR TKI resistance.
- What have data shown with treatment strategies using dual targeting of HER3 and EGFR?
- Please review the rationale and study design for HERTHENA-Lung01 and discuss emerging study data and its implications on the treatment landscape. (
Goto, et al. WCLC 2023. Abstract OA05.03 ;Johnson, et al. ESMO 2023. Abstract 1319MO )- Briefly outline the study design and key endpoints. What are your perceptions around the brain mets data presented at ESMO this past year?
- What are some key takeaways from safety data?
- What implications may these findings have on clinical practice?
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