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Opinion|Videos|January 9, 2026

iMMagine-1 Trial: Data for Anito-Cel in R/R Myeloma After 3 Prior Lines of Therapy

Author(s)Krina K. Patel, MD, MSc, Matthew J. Frigault, MD

Krina K. Patel, MD, MSc, and Matthew J. Frigault, MD, discuss findings from the iMMagine-1 of anito-cel in relapsed/refractory multiple myeloma.

Episodes in this series

2 experts are featured in this series

EP. 1 Treatment Approaches for Multiple Myeloma in the Fourth Line and Beyond

2 experts are featured in this series

EP. 2 Rationale Driving Additional CAR T-Cell Therapy Research in Myeloma

2 experts are featured in this series

EP. 3 Role of Bridging Therapy With CAR T-Cell Therapy in Multiple Myeloma

2 experts are featured in this series

EP. 4 Exploring the Novel CAR T-Cell Therapy Anito-Cel in Multiple Myeloma

2 experts are featured in this series

EP. 5 iMMagine-1 Trial: Data for Anito-Cel in R/R Myeloma After 3 Prior Lines of Therapy

2 experts are featured in this series

EP. 6 CAR T-Cell Therapy Targets Beyond BCMA in Multiple Myeloma

2 experts are featured in this series

EP. 7 Other Key Myeloma CAR T-Cell Therapy Data From ASH 2025

2 experts are featured in this series

EP. 8 Persisting Questions With CAR T-Cell Therapy in Multiple Myeloma

Krina K. Patel, MD, MSc, and Matthew J. Frigault, MD, review data from the phase 2 iMMagine-1 trial (NCT05396885) evaluating anitocabtagene autoleucel (anito-cel) in relapsed or refractory multiple myeloma after three prior lines of therapy. They discuss efficacy outcomes, safety observations, and depth of response reported in the study. Patel and Frigault place these findings in context of current CAR T-cell therapy benchmarks.

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