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Opinion|Videos|December 23, 2025

Rationale Driving Additional CAR T-Cell Therapy Research in Myeloma

Author(s)Krina K. Patel, MD, MSc, Matthew J. Frigault, MD

Krina K. Patel, MD, MSc, and Matthew J. Frigault, MD, detail the drive beyond additional CAR T-cell therapy research in multiple myeloma.

Episodes in this series

2 experts are featured in this series

EP. 1 Treatment Approaches for Multiple Myeloma in the Fourth Line and Beyond

2 experts are featured in this series

EP. 2 Rationale Driving Additional CAR T-Cell Therapy Research in Myeloma

2 experts are featured in this series

EP. 3 Role of Bridging Therapy With CAR T-Cell Therapy in Multiple Myeloma

2 experts are featured in this series

EP. 4 Exploring the Novel CAR T-Cell Therapy Anito-Cel in Multiple Myeloma

2 experts are featured in this series

EP. 5 iMMagine-1 Trial: Data for Anito-Cel in R/R Myeloma After 3 Prior Lines of Therapy

2 experts are featured in this series

EP. 6 CAR T-Cell Therapy Targets Beyond BCMA in Multiple Myeloma

2 experts are featured in this series

EP. 7 Other Key Myeloma CAR T-Cell Therapy Data From ASH 2025

2 experts are featured in this series

EP. 8 Persisting Questions With CAR T-Cell Therapy in Multiple Myeloma

Krina K. Patel, MD, MSc, and Matthew J. Frigault, MD, explore the scientific and clinical rationale supporting continued CAR T-cell therapy research in multiple myeloma. They discuss limitations of existing products, including durability of response and access challenges. Patel and Frigault explain how next-generation constructs aim to address these unmet needs.

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