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Opinion|Videos|December 23, 2025

Treatment Approaches for Multiple Myeloma in the Fourth Line and Beyond

Author(s)Krina K. Patel, MD, MSc, Matthew J. Frigault, MD

Krina K. Patel, MD, MSc, and Matthew J. Frigault, MD, discuss treatment approaches in fourth- and later-line multiple myeloma.

Episodes in this series

2 experts are featured in this series

EP. 1 Treatment Approaches for Multiple Myeloma in the Fourth Line and Beyond

2 experts are featured in this series

EP. 2 Rationale Driving Additional CAR T-Cell Therapy Research in Myeloma

2 experts are featured in this series

EP. 3 Role of Bridging Therapy With CAR T-Cell Therapy in Multiple Myeloma

2 experts are featured in this series

EP. 4 Exploring the Novel CAR T-Cell Therapy Anito-Cel in Multiple Myeloma

2 experts are featured in this series

EP. 5 iMMagine-1 Trial: Data for Anito-Cel in R/R Myeloma After 3 Prior Lines of Therapy

2 experts are featured in this series

EP. 6 CAR T-Cell Therapy Targets Beyond BCMA in Multiple Myeloma

2 experts are featured in this series

EP. 7 Other Key Myeloma CAR T-Cell Therapy Data From ASH 2025

2 experts are featured in this series

EP. 8 Persisting Questions With CAR T-Cell Therapy in Multiple Myeloma

Krina K. Patel, MD, MSc, and Matthew J. Frigault, MD, discuss current treatment approaches for patients with multiple myeloma in the fourth line and beyond. They review how disease biology, prior therapies, and patient fitness influence sequencing decisions in this heavily pretreated setting. Patel and Frigault also place CAR T-cell therapy within the broader landscape of available later-line options.

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