Is There a Role for Cabozantinib in the First-Line Setting in Advanced RCC in Certain Populations?

EP: 1.Advanced RCC: Brief Overview

EP: 2.First-Line Therapy of Advanced RCC With Lenvatinib + Pembrolizumab: CLEAR Study

EP: 3.First-Line Therapy of Advanced RCC With Axitinib + Pembrolizumab: KEYNOTE-426 Study

EP: 4.First-Line Therapy of Advanced RCC With Cabozantinib + Nivolumab: CheckMate 9ER Study

EP: 5.First-Line Therapy of Advanced RCC With Nivolumab + Ipilimumab: CheckMate 214 Study

EP: 6.What Factors Should be Taken Into Consideration When Choosing The Fist-Line Therapy in RCC?

EP: 7.Choosing The Appropriate Frontline Therapy in Advanced RCC: IO-TKI vs IO-IO Therapies

EP: 8.Treatment Strategies for Patients With RCC and Brain or Bone Metastases

EP: 9.Is There a Role for Biomarkers in Advanced RCC?

EP: 10.Quality of Life Data From Clinical Trials in RCC

EP: 11.The Evaluation of Novel Agents and Combination Regimens in the First-Line Setting in RCC

EP: 12.Triplet Regimens in Development for Patients With RCC

EP: 13.Adjuvant Systemic Therapies for Patients With RCC Post-Nephrectomy

EP: 14.Impact of Adjuvant Therapy on Treatment Selection in Advanced RCC

EP: 15.Ongoing Clinical Trials in the Adjuvant Setting in RCC

EP: 16.Ongoing Clinical Trials in the Neoadjuvant Setting in RCC

EP: 17.The Impact of Neoadjuvant Therapy on Treatment Selection in Advanced RCC

EP: 18.Treatment Options in the Second-Line and Beyond in Advanced RCC

EP: 19.Sequencing Therapies in the Second Line and Beyond in Advanced RCC

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EP: 20.Is There a Role for Cabozantinib in the First-Line Setting in Advanced RCC in Certain Populations?

EP: 21.Unmet Needs and Future Perspectives in Advanced RCC

Tian Zhang, MD: Dr Bilen, how comfortable are we using cabozantinib as a first-line treatment option, given the recent availability of adjuvant therapies in addition to cabozantinib in combination in the frontline setting?

Mehmet A. Bilen, MD: In general, cabozantinib has a broad data set, like in RCC [renal cell carcinoma]. First, was the METEOR trial in the salvage setting. Then, CABOSUN in the front-line setting. Most recently, CheckMate 9ER showed the efficacy of cabozantinib with immune checkpoint inhibitors. Thus, we know this agent is working in different lines. In addition, there are a number of real-world data also showing the effectiveness of cabozantinib plus VEGF plus I/O [immuno-oncology]. Because of this, cabozantinib is 1 agent we use after adjuvant immunotherapy.

Dr [David] Braun mentioned earlier that the type of failure from adjuvant immunotherapy is very important. If this is a failure that happened during, if this is a rapid failure, and if we see problem sites of metastases like the bone and liver, then this is 1 drug I use as a single agent or with immune checkpoint inhibitors.

This transcript has been edited for clarity.