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Opinion|Videos|March 7, 2025

Long-Term Data From CheckMate 9ER Investigating Nivolumab Plus Cabozantinib in Untreated Advanced RCC

Author(s)Pedro C. Barata, MD, MSc, FACP , Moshe Ornstein, MD, Elizabeth Wulff-Burchfield, MD

Experts discuss the key findings from the final follow-up results of the CheckMate 9ER trial, evaluating nivolumab plus cabozantinib in advanced renal cell carcinoma (RCC) and share perspectives on the clinical implications of these updated data, along with insights from other studies of note, including LITESPARK-003 (belzutifan plus cabozantinib) and LITESPARK-024 (belzutifan plus palbociclib).

Episodes in this series

EP. 1 Long-Term Outcomes in Advanced RCC: Analyzing 8 Years of CheckMate 214 Data

EP. 1 Long-Term Outcomes in Advanced RCC: Analyzing 8 Years of CheckMate 214 Data

EP. 2 Optimizing IO-TKI Selection: Patient-Specific Approaches for Optimal Outcomes

EP. 2 Optimizing IO-TKI Selection: Patient-Specific Approaches for Optimal Outcomes

EP. 3 Long-Term Data From CheckMate 9ER Investigating Nivolumab Plus Cabozantinib in Untreated Advanced RCC

EP. 3 Long-Term Data From CheckMate 9ER Investigating Nivolumab Plus Cabozantinib in Untreated Advanced RCC

EP. 4 RCC Treatment Selection: Expert Perspectives on Long-Term Data and Insights on Treatment Selection

EP. 4 RCC Treatment Selection: Expert Perspectives on Long-Term Data and Insights on Treatment Selection

EP. 5 Optimizing IO/TKI Success: Managing Adverse Effects and Personalizing Treatment

EP. 5 Optimizing IO/TKI Success: Managing Adverse Effects and Personalizing Treatment

EP. 6 Navigating RCC Progression: Optimizing Treatment Sequence After the First Line

EP. 6 Navigating RCC Progression: Optimizing Treatment Sequence After the First Line

EP. 7 Postimmunotherapy Options in RCC: Latest Trial Data and Expert Perspectives on Rechallenge Strategies

EP. 7 Postimmunotherapy Options in RCC: Latest Trial Data and Expert Perspectives on Rechallenge Strategies

EP. 8 Emerging Therapies in RCC: Shaping Future Treatment Sequences

EP. 8 Emerging Therapies in RCC: Shaping Future Treatment Sequences

EP. 9 RCC Treatment Evolution: Expert Perspectives on the Evolving Landscape and Advances From ASCO GU 2025

EP. 9 RCC Treatment Evolution: Expert Perspectives on the Evolving Landscape and Advances From ASCO GU 2025

Video content above is prompted by the following:

The CheckMate 9ER trial established the efficacy of nivolumab plus cabozantinib in advanced RCC. Could you review the key findings from the final follow-up results and share your perspectives on the clinical implications of these updated data?
- Please feel free to highlight other studies of note:
  - LITESPARK-003 (belzutifan plus cabozantinib)
  - LITESPARK-024 (belzutifan plus palbociclib)

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