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Opinion|Videos|March 21, 2025

Postimmunotherapy Options in RCC: Latest Trial Data and Expert Perspectives on Rechallenge Strategies

Author(s)Pedro C. Barata, MD, MSc, FACP , Moshe Ornstein, MD, Elizabeth Wulff-Burchfield, MD

Experts discuss key findings from the phase 3 CONTACT-03 trial investigating atezolizumab plus cabozantinib vs cabozantinib alone in inoperable advanced renal cell carcinoma (aRCC) after immune checkpoint inhibitor (ICI) treatment, along with insights from real-world data on sequencing strategies and the efficacy of tyrosine kinase inhibitors (TKIs) after prior ICI therapy.

Episodes in this series

EP. 1 Long-Term Outcomes in Advanced RCC: Analyzing 8 Years of CheckMate 214 Data

EP. 1 Long-Term Outcomes in Advanced RCC: Analyzing 8 Years of CheckMate 214 Data

EP. 2 Optimizing IO-TKI Selection: Patient-Specific Approaches for Optimal Outcomes

EP. 2 Optimizing IO-TKI Selection: Patient-Specific Approaches for Optimal Outcomes

EP. 3 Long-Term Data From CheckMate 9ER Investigating Nivolumab Plus Cabozantinib in Untreated Advanced RCC

EP. 3 Long-Term Data From CheckMate 9ER Investigating Nivolumab Plus Cabozantinib in Untreated Advanced RCC

EP. 4 RCC Treatment Selection: Expert Perspectives on Long-Term Data and Insights on Treatment Selection

EP. 4 RCC Treatment Selection: Expert Perspectives on Long-Term Data and Insights on Treatment Selection

EP. 5 Optimizing IO/TKI Success: Managing Adverse Effects and Personalizing Treatment

EP. 5 Optimizing IO/TKI Success: Managing Adverse Effects and Personalizing Treatment

EP. 6 Navigating RCC Progression: Optimizing Treatment Sequence After the First Line

EP. 6 Navigating RCC Progression: Optimizing Treatment Sequence After the First Line

EP. 7 Postimmunotherapy Options in RCC: Latest Trial Data and Expert Perspectives on Rechallenge Strategies

EP. 7 Postimmunotherapy Options in RCC: Latest Trial Data and Expert Perspectives on Rechallenge Strategies

EP. 8 Emerging Therapies in RCC: Shaping Future Treatment Sequences

EP. 8 Emerging Therapies in RCC: Shaping Future Treatment Sequences

EP. 9 RCC Treatment Evolution: Expert Perspectives on the Evolving Landscape and Advances From ASCO GU 2025

EP. 9 RCC Treatment Evolution: Expert Perspectives on the Evolving Landscape and Advances From ASCO GU 2025

Video content above is prompted by the following:

Could you highlight key findings from the phase 3 CONTACT-03 trial investigating atezolizumab plus cabozantinib vs cabozantinib in inoperable aRCC after ICI treatment and other relevant studies?
What insights do real-world data and experience provide about sequencing strategies and the efficacy of TKIs after prior ICI therapy?
Real-world outcomes with cabozantinib after prior ICI
Are there any patients in which you consider immunotherapy rechallenge after progression on initial ICI-based therapy? How might you differentiate between rechallenging with PD-L1 inhibitors vs CTLA-4-based approaches?
What insights do emerging data, such as the TiNivo-3 trial, provide regarding this strategy? Phase 3 TiNivo-2 trial investigating tivozanib ± nivolumab after an ICI

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