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Opinion|Videos|February 28, 2025

Long-Term Outcomes in Advanced RCC: Analyzing 8 Years of CheckMate 214 Data

Author(s)Pedro C. Barata, MD, MSc, FACP , Moshe Ornstein, MD, Elizabeth Wulff-Burchfield, MD

Experts discuss the 8-year follow-up data from the CheckMate 214 trial evaluating nivolumab plus ipilimumab for first-line treatment of advanced renal cell carcinoma (RCC), and how these mature overall survival (OS) data influence the view of nivolumab plus ipilimumab as a frontline option, alongside insights from efficacy, safety, post hoc subgroup analyses (Albiges et al, Eur Urol, 2022), and health-related quality of life (HRQOL) data (Cella et al, J Clin Oncol, 2022).

Episodes in this series

EP. 1 Long-Term Outcomes in Advanced RCC: Analyzing 8 Years of CheckMate 214 Data

EP. 1 Long-Term Outcomes in Advanced RCC: Analyzing 8 Years of CheckMate 214 Data

EP. 2 Optimizing IO-TKI Selection: Patient-Specific Approaches for Optimal Outcomes

EP. 2 Optimizing IO-TKI Selection: Patient-Specific Approaches for Optimal Outcomes

EP. 3 Long-Term Data From CheckMate 9ER Investigating Nivolumab Plus Cabozantinib in Untreated Advanced RCC

EP. 3 Long-Term Data From CheckMate 9ER Investigating Nivolumab Plus Cabozantinib in Untreated Advanced RCC

EP. 4 RCC Treatment Selection: Expert Perspectives on Long-Term Data and Insights on Treatment Selection

EP. 4 RCC Treatment Selection: Expert Perspectives on Long-Term Data and Insights on Treatment Selection

EP. 5 Optimizing IO/TKI Success: Managing Adverse Effects and Personalizing Treatment

EP. 5 Optimizing IO/TKI Success: Managing Adverse Effects and Personalizing Treatment

EP. 6 Navigating RCC Progression: Optimizing Treatment Sequence After the First Line

EP. 6 Navigating RCC Progression: Optimizing Treatment Sequence After the First Line

EP. 7 Postimmunotherapy Options in RCC: Latest Trial Data and Expert Perspectives on Rechallenge Strategies

EP. 7 Postimmunotherapy Options in RCC: Latest Trial Data and Expert Perspectives on Rechallenge Strategies

EP. 8 Emerging Therapies in RCC: Shaping Future Treatment Sequences

EP. 8 Emerging Therapies in RCC: Shaping Future Treatment Sequences

EP. 9 RCC Treatment Evolution: Expert Perspectives on the Evolving Landscape and Advances From ASCO GU 2025

EP. 9 RCC Treatment Evolution: Expert Perspectives on the Evolving Landscape and Advances From ASCO GU 2025

Video content above is prompted by the following:

Please walk us though the 8-year follow-up data from the CheckMate 214 trial evaluating nivolumab plusipilimumab for first-line treatment of advanced RCC.
How do these mature OS data influence your view of nivolumab plusipilimumab as a frontline option?
Please share your insights from efficacy and safety data, post hoc subgroup analyses, or HRQOL data. How you interpret these data?

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