
Opinion|Videos|February 28, 2025
Optimizing IO-TKI Selection: Patient-Specific Approaches for Optimal Outcomes
Experts discuss how emerging novel doublet regimens in the frontline setting for advanced renal cell carcinoma may address current unmet needs, highlighting specific biomarkers, patient populations, and clinical scenarios where these combinations could offer distinct advantages over existing standards like immunotherapy (IO)/IO or established IO/tyrosine kinase inhibitor (TKI) combinations.
Advertisement
Episodes in this series

Video content above is prompted by the following:
- With novel doublet regimens emerging in the frontline setting for advanced RCC, how do you see these combinations addressing current unmet needs?
- Are there specific biomarkers, patient populations, or clinical scenarios where these regimens might offer distinct advantages over existing standards like IO/IO or established IO/TKI combinations?
Advertisement
Related to this article

The top 5 OncLive TV videos of the week cover insights in ovarian cancer, breast cancer, head and neck cancer, pancreatic cancer, and follicular lymphoma.

Adanma Ayanambakkam, MD, MS, discusses findings from the FIT-001 trial of darlifarnib plus cabozantinib in RCC.

UroGen submitted an NDA for UGN-103 in recurrent NMIBC, T-DXd improved PFS in first-line HER2-mutant lung cancer, and more.

In a phase 1/2 study, the LSD1 inhibitor bomedemstat reduced spleen volume, improved symptoms, and lowered driver mutation burden in patients with advanced myelofibrosis.

Neeta Somaiah, MD, discusses the significance of the Peak study and what an approval of bezuclastinib plus sunitinib would mean for GIST.

Sara Nunnery, MD, MSCI, and Irene M. Kang, MD, discuss toxicity and monitoring considerations for the use of ADCs in metastatic TNBC.

The NMPA accepted the NDA for the PD-L1/4-1BB–directed bispecific antibody opamtistomig in previously treated advanced extrapulmonary NEC.
Advertisement
Advertisement
Trending on OncLive
1
ASCO Issues First Guideline on ctDNA Testing in Solid Tumors and Lymphoma
2
Intismeran Autogene Plus Pembrolizumab Meets RFS and DMFS End Points in Resected Stage IIB-IV Melanoma
3
Darlifarnib Plus Cabozantinib Displays Early Signals of Safety and Efficacy in RCC
4
The OncFive: Top Oncology Articles for the Week of 8/16
5


