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Opinion|Videos|March 14, 2025

Optimizing IO/TKI Success: Managing Adverse Effects and Personalizing Treatment

Author(s)Pedro C. Barata, MD, MSc, FACP , Moshe Ornstein, MD, Elizabeth Wulff-Burchfield, MD

Experts discuss regimens with the most favorable toxicity profiles and how they personalize treatment to minimize patient burden, while also exploring preferred strategies for patients who have completed pembrolizumab in the adjuvant setting and how the timing of recurrence relative to adjuvant therapy completion influences treatment selection.

Episodes in this series

EP. 1 Long-Term Outcomes in Advanced RCC: Analyzing 8 Years of CheckMate 214 Data

EP. 1 Long-Term Outcomes in Advanced RCC: Analyzing 8 Years of CheckMate 214 Data

EP. 2 Optimizing IO-TKI Selection: Patient-Specific Approaches for Optimal Outcomes

EP. 2 Optimizing IO-TKI Selection: Patient-Specific Approaches for Optimal Outcomes

EP. 3 Long-Term Data From CheckMate 9ER Investigating Nivolumab Plus Cabozantinib in Untreated Advanced RCC

EP. 3 Long-Term Data From CheckMate 9ER Investigating Nivolumab Plus Cabozantinib in Untreated Advanced RCC

EP. 4 RCC Treatment Selection: Expert Perspectives on Long-Term Data and Insights on Treatment Selection

EP. 4 RCC Treatment Selection: Expert Perspectives on Long-Term Data and Insights on Treatment Selection

EP. 5 Optimizing IO/TKI Success: Managing Adverse Effects and Personalizing Treatment

EP. 5 Optimizing IO/TKI Success: Managing Adverse Effects and Personalizing Treatment

EP. 6 Navigating RCC Progression: Optimizing Treatment Sequence After the First Line

EP. 6 Navigating RCC Progression: Optimizing Treatment Sequence After the First Line

EP. 7 Postimmunotherapy Options in RCC: Latest Trial Data and Expert Perspectives on Rechallenge Strategies

EP. 7 Postimmunotherapy Options in RCC: Latest Trial Data and Expert Perspectives on Rechallenge Strategies

EP. 8 Emerging Therapies in RCC: Shaping Future Treatment Sequences

EP. 8 Emerging Therapies in RCC: Shaping Future Treatment Sequences

EP. 9 RCC Treatment Evolution: Expert Perspectives on the Evolving Landscape and Advances From ASCO GU 2025

EP. 9 RCC Treatment Evolution: Expert Perspectives on the Evolving Landscape and Advances From ASCO GU 2025

Video content above is prompted by the following:

What regimens have you found to offer the most favorable toxicity profile? How do you personalize treatment to minimize patient burden?
What are your preferred strategies for patients who have completed pembrolizumab in the adjuvant setting?
How does the timing of recurrence relative to adjuvant therapy completion influence your treatment selection?
Please discuss which patients might still be candidates for initial active surveillance. Which factors prompt you to consider active surveillance rather than immediate systemic therapy?

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