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Opinion|Videos|March 19, 2026

Optimizing Future Combination Approaches in Myelofibrosis

Author(s)Prithviraj Bose, MD, Pankit Vachhani, MD

Prithviraj Bose, MD, and Pankit Vachhani, MD, discuss how future

Episodes in this series

EP. 1 The Limitations of JAK Inhibitors in Myelofibrosis Management

EP. 1 The Limitations of JAK Inhibitors in Myelofibrosis Management

EP. 2 When to Initiate Therapy in Myelofibrosis: The Role of Early Intervention

EP. 2 When to Initiate Therapy in Myelofibrosis: The Role of Early Intervention

EP. 3 Background on the Investigation of Selinexor in Myelofibrosis

EP. 3 Background on the Investigation of Selinexor in Myelofibrosis

EP. 4 The SENTRY Trial: Selinexor Plus Ruxolitinib in JAK Inhibitor–Naive Myelofibrosis

EP. 4 The SENTRY Trial: Selinexor Plus Ruxolitinib in JAK Inhibitor–Naive Myelofibrosis

EP. 5 Key Findings to Watch in SENTRY Trial of Selinexor/Ruxolitinib in Myelofibrosis

EP. 5 Key Findings to Watch in SENTRY Trial of Selinexor/Ruxolitinib in Myelofibrosis

EP. 6 How Selinexor Plus Ruxolitinib Could Affect Frontline Myelofibrosis Management

EP. 6 How Selinexor Plus Ruxolitinib Could Affect Frontline Myelofibrosis Management

EP. 7 Optimizing Future Combination Approaches in Myelofibrosis

EP. 7 Optimizing Future Combination Approaches in Myelofibrosis

Prithviraj Bose, MD, and Pankit Vachhani, MD, discuss future directions for optimizing combination treatment strategies in myelofibrosis. Bose highlights emerging agents and rational combinations targeting fibrosis, inflammation, and malignant clone biology. Vachhani emphasizes the importance of personalized treatment approaches and ongoing clinical trials aimed at improving survival and quality of life.

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