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Opinion|Videos|March 12, 2026

How Selinexor Plus Ruxolitinib Could Affect Frontline Myelofibrosis Management

Author(s)Prithviraj Bose, MD, Pankit Vachhani, MD

Prithviraj Bose, MD, and Pankit Vachhani, MD, discuss how selinexor plus ruxolitinib could affect the frontline myelofibrosis treatment paradigm.

Episodes in this series

EP. 1 The Limitations of JAK Inhibitors in Myelofibrosis Management

EP. 1 The Limitations of JAK Inhibitors in Myelofibrosis Management

EP. 2 When to Initiate Therapy in Myelofibrosis: The Role of Early Intervention

EP. 2 When to Initiate Therapy in Myelofibrosis: The Role of Early Intervention

EP. 3 Background on the Investigation of Selinexor in Myelofibrosis

EP. 3 Background on the Investigation of Selinexor in Myelofibrosis

EP. 4 The SENTRY Trial: Selinexor Plus Ruxolitinib in JAK Inhibitor–Naive Myelofibrosis

EP. 4 The SENTRY Trial: Selinexor Plus Ruxolitinib in JAK Inhibitor–Naive Myelofibrosis

EP. 5 Key Findings to Watch in SENTRY Trial of Selinexor/Ruxolitinib in Myelofibrosis

EP. 5 Key Findings to Watch in SENTRY Trial of Selinexor/Ruxolitinib in Myelofibrosis

EP. 6 How Selinexor Plus Ruxolitinib Could Affect Frontline Myelofibrosis Management

EP. 6 How Selinexor Plus Ruxolitinib Could Affect Frontline Myelofibrosis Management

EP. 7 Optimizing Future Combination Approaches in Myelofibrosis

EP. 7 Optimizing Future Combination Approaches in Myelofibrosis

Prithviraj Bose, MD, and Pankit Vachhani, MD, explore how positive results from the phase 3 SENTRY trial (NCT04562389) could influence the frontline treatment paradigm for myelofibrosis. Bose discusses the potential for combination therapy with selinexor (Xpovio) plus ruxolitinib (Jakafi) to move beyond symptom control toward disease modification. Vachhani considers patient populations that may derive the greatest benefit and how treatment sequencing strategies could evolve.

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