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Opinion|Videos|February 26, 2026

When to Initiate Therapy in Myelofibrosis: The Role of Early Intervention

Author(s)Prithviraj Bose, MD, Pankit Vachhani, MD

Prithviraj Bose, MD, and Pankit Vachhani, MD, discuss the importance of early intervention and when to initiate treatment in myelofibrosis.

Episodes in this series

EP. 1 The Limitations of JAK Inhibitors in Myelofibrosis Management

EP. 1 The Limitations of JAK Inhibitors in Myelofibrosis Management

EP. 2 When to Initiate Therapy in Myelofibrosis: The Role of Early Intervention

EP. 2 When to Initiate Therapy in Myelofibrosis: The Role of Early Intervention

EP. 3 Background on the Investigation of Selinexor in Myelofibrosis

EP. 3 Background on the Investigation of Selinexor in Myelofibrosis

EP. 4 The SENTRY Trial: Selinexor Plus Ruxolitinib in JAK Inhibitor–Naive Myelofibrosis

EP. 4 The SENTRY Trial: Selinexor Plus Ruxolitinib in JAK Inhibitor–Naive Myelofibrosis

EP. 5 Key Findings to Watch in SENTRY Trial of Selinexor/Ruxolitinib in Myelofibrosis

EP. 5 Key Findings to Watch in SENTRY Trial of Selinexor/Ruxolitinib in Myelofibrosis

EP. 6 How Selinexor Plus Ruxolitinib Could Affect Frontline Myelofibrosis Management

EP. 6 How Selinexor Plus Ruxolitinib Could Affect Frontline Myelofibrosis Management

EP. 7 Optimizing Future Combination Approaches in Myelofibrosis

EP. 7 Optimizing Future Combination Approaches in Myelofibrosis

Prithviraj Bose, MD, and Pankit Vachhani, MD, examine considerations surrounding treatment initiation and the potential role of earlier therapeutic intervention in myelofibrosis. Bose discusses risk stratification, symptom burden, and disease trajectory as key factors influencing timing of therapy. Vachhani highlights emerging perspectives that earlier intervention may alter disease course and improve outcomes compared with delayed treatment strategies.

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