Opinion|Videos|February 26, 2026
When to Initiate Therapy in Myelofibrosis: The Role of Early Intervention
Author(s)Prithviraj Bose, MD, Pankit Vachhani, MD
Prithviraj Bose, MD, and Pankit Vachhani, MD, discuss the importance of early intervention and when to initiate treatment in myelofibrosis.
Advertisement
Episodes in this series
Prithviraj Bose, MD, and Pankit Vachhani, MD, examine considerations surrounding treatment initiation and the potential role of earlier therapeutic intervention in myelofibrosis. Bose discusses risk stratification, symptom burden, and disease trajectory as key factors influencing timing of therapy. Vachhani highlights emerging perspectives that earlier intervention may alter disease course and improve outcomes compared with delayed treatment strategies.
Advertisement
Related to this article
The filing is supported by phase 3 REZILIENT3 data showing a median PFS of 14.5 vs 8.5 months with zipalertinib plus chemotherapy vs chemotherapy.
A European Commission decision on belzutifan plus lenvatinib in pretreated advanced ccRCC is expected within 2 months, based on LITESPARK-011 data.
The phase 3 4WARD trial is evaluating mavorixafor for reducing infection rates and raising neutrophil counts in patients with primary chronic neutropenia.
Did you catch all of this week's top oncology news? Test your knowledge with OncLive's Weekly News Quiz.
Age, geographic location, transportation barriers, and language and communication barriers may limit patient opportunities to participate in research.
Targeting two alternate pathways at the same time led to improved outcomes in multiple preclinical models of advanced breast cancer.
Updated LEGEND cohort 1 data showed a 56% CR rate and a 24% 12-month CR rate with detalimogene in BCG-unresponsive, high-risk NMIBC with CIS.
Phase 2 Co-PSMA data showed higher lesion detection with 64Cu-SAR-bisPSMA vs 68Ga-PSMA-11 in biochemical recurrence after prostatectomy.
Advertisement
Advertisement
Trending on OncLive
1
Dr Wander on the Evolving First-Line and Post–T-DXd Landscape in HER2+ Metastatic Breast Cancer
2
Combination Therapy Overcomes Treatment Resistance in Breast Cancer Models
3
Dr Levy on Where Iza-Bren May Fit Following Osimertinib In EGFR-Mutated NSCLC
4
Dr Levy on How the EGFR-Targeted Therapy Landscape Has Evolved in NSCLC
5