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Opinion|Videos|February 26, 2026

The Limitations of JAK Inhibitors in Myelofibrosis Management

Author(s)Prithviraj Bose, MD, Pankit Vachhani, MD

Prithviraj Bose, MD, and Pankit Vachhani, MD, discuss the limitations of currently approved JAK inhibitors in the treatment of myelofibrosis.

Episodes in this series

EP. 1 The Limitations of JAK Inhibitors in Myelofibrosis Management

EP. 1 The Limitations of JAK Inhibitors in Myelofibrosis Management

EP. 2 When to Initiate Therapy in Myelofibrosis: The Role of Early Intervention

EP. 2 When to Initiate Therapy in Myelofibrosis: The Role of Early Intervention

EP. 3 Background on the Investigation of Selinexor in Myelofibrosis

EP. 3 Background on the Investigation of Selinexor in Myelofibrosis

EP. 4 The SENTRY Trial: Selinexor Plus Ruxolitinib in JAK Inhibitor–Naive Myelofibrosis

EP. 4 The SENTRY Trial: Selinexor Plus Ruxolitinib in JAK Inhibitor–Naive Myelofibrosis

EP. 5 Key Findings to Watch in SENTRY Trial of Selinexor/Ruxolitinib in Myelofibrosis

EP. 5 Key Findings to Watch in SENTRY Trial of Selinexor/Ruxolitinib in Myelofibrosis

EP. 6 How Selinexor Plus Ruxolitinib Could Affect Frontline Myelofibrosis Management

EP. 6 How Selinexor Plus Ruxolitinib Could Affect Frontline Myelofibrosis Management

EP. 7 Optimizing Future Combination Approaches in Myelofibrosis

EP. 7 Optimizing Future Combination Approaches in Myelofibrosis

Prithviraj Bose, MD, and Pankit Vachhani, MD, discuss the clinical limitations of currently approved JAK inhibitors in the management of myelofibrosis. Bose reviews challenges such as incomplete disease modification, persistence of cytopenias, and suboptimal durability of spleen and symptom responses in some patients. Vachhani emphasizes the need for novel combination approaches that address underlying disease biology and improve long-term outcomes beyond symptomatic control.

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