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Opinion|Videos|March 12, 2026

Key Findings to Watch in SENTRY Trial of Selinexor/Ruxolitinib in Myelofibrosis

Author(s)Prithviraj Bose, MD, Pankit Vachhani, MD

Prithviraj Bose, MD, and Pankit Vachhani, MD, discuss the key objectives of the phase 3 SENTRY trial evaluating selinexor plus ruxolitinib in JAK inhibitor–naive myelofibrosis.

Episodes in this series

EP. 1 The Limitations of JAK Inhibitors in Myelofibrosis Management

EP. 1 The Limitations of JAK Inhibitors in Myelofibrosis Management

EP. 2 When to Initiate Therapy in Myelofibrosis: The Role of Early Intervention

EP. 2 When to Initiate Therapy in Myelofibrosis: The Role of Early Intervention

EP. 3 Background on the Investigation of Selinexor in Myelofibrosis

EP. 3 Background on the Investigation of Selinexor in Myelofibrosis

EP. 4 The SENTRY Trial: Selinexor Plus Ruxolitinib in JAK Inhibitor–Naive Myelofibrosis

EP. 4 The SENTRY Trial: Selinexor Plus Ruxolitinib in JAK Inhibitor–Naive Myelofibrosis

EP. 5 Key Findings to Watch in SENTRY Trial of Selinexor/Ruxolitinib in Myelofibrosis

EP. 5 Key Findings to Watch in SENTRY Trial of Selinexor/Ruxolitinib in Myelofibrosis

EP. 6 How Selinexor Plus Ruxolitinib Could Affect Frontline Myelofibrosis Management

EP. 6 How Selinexor Plus Ruxolitinib Could Affect Frontline Myelofibrosis Management

EP. 7 Optimizing Future Combination Approaches in Myelofibrosis

EP. 7 Optimizing Future Combination Approaches in Myelofibrosis

Prithviraj Bose, MD, and Pankit Vachhani, MD, discuss the primary objectives and clinically meaningful end points of the phase 3 SENTRY trial (NCT04562389). Bose highlights key efficacy measures such as spleen response, symptom improvement, and durability of benefit that will determine the regimen’s clinical impact. Vachhani also notes the importance of safety and tolerability data in assessing the feasibility of incorporating combination therapy with selinexor (Xpovio) plus ruxolitinib (Jakafi) into routine practice.

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