Opinion|Videos|March 12, 2026
Key Findings to Watch in SENTRY Trial of Selinexor/Ruxolitinib in Myelofibrosis
Author(s)Prithviraj Bose, MD, Pankit Vachhani, MD
Prithviraj Bose, MD, and Pankit Vachhani, MD, discuss the key objectives of the phase 3 SENTRY trial evaluating selinexor plus ruxolitinib in JAK inhibitor–naive myelofibrosis.
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Prithviraj Bose, MD, and Pankit Vachhani, MD, discuss the primary objectives and clinically meaningful end points of the phase 3 SENTRY trial (NCT04562389). Bose highlights key efficacy measures such as spleen response, symptom improvement, and durability of benefit that will determine the regimen’s clinical impact. Vachhani also notes the importance of safety and tolerability data in assessing the feasibility of incorporating combination therapy with selinexor (Xpovio) plus ruxolitinib (Jakafi) into routine practice.
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