Opinion|Videos|March 5, 2026
Background on the Investigation of Selinexor in Myelofibrosis
Author(s)Prithviraj Bose, MD, Pankit Vachhani, MD
Prithviraj Bose, MD, and Pankit Vachhani, MD, discuss the mechanism of action of selinexor and the rationale for investigating the agent in myelofibrosis.
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Prithviraj Bose, MD, and Pankit Vachhani, MD, review the biological rationale for investigating selinexor (Xpovio) in myelofibrosis. Bose explains the mechanism of action of selective nuclear export inhibition and its potential effects on malignant hematopoietic signaling pathways. Vachhani discusses how combining selinexor with JAK inhibition may provide synergistic activity to improve clinical responses.
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