Vol. 18/No. 15 | OncologyLive

TRK Inhibitors Advance Rapidly in "Tumor-Agnostic" Paradigm

August 04, 2017

The growing use of next-generation sequencing has only recently revealed the neurotrophic tropomyosin receptor kinase (NTRK) gene presence across a wide range of tumor types and piqued interest in their potential as anticancer targets.

Genomic Landscape of Prostate Cancer Aligns With Breast Cancer Subtypes

August 04, 2017

A comparison of the genomic risk profiles of patients with low-risk prostate cancer who are candidates for active surveillance against higher-risk patients, discovered that substantial genomic heterogeneity exists among patients with prostate cancer.

XPO1 Inhibitor Offers Novel Mechanism for Treating Penta-Refractory Myeloma

August 03, 2017

Selinexor (KPT-330), a small-molecule inhibitor with a novel mechanism of action, is being investigated in patients with multiple myeloma who have become refractory to the many new options that have been introduced in recent years for patients with the malignancy.

Biomarker Basics: A Look at MSI's Growing Role

August 02, 2017

The recent approval of 2 immunotherapies for the treatment of certain patients with tumors that exhibit microsatellite instability has propelled the emerging biomarker into clinical practice, prompting calls for broader genetic testing.

New Strategy Boosts Microenvironment to Promote Antitumor Immunity in GI Metastases

August 01, 2017

Despite the promise of immunotherapy for treating patients with advanced cancers, the success of using such therapies for progressive gastrointestinal malignancies such as colorectal liver metastases (CRLM) has been limited so far.