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Latest from Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

First-Line Treatment for EGFR-Mutant Advanced Lung Cancer
ByBenjamin P. Levy, MD,Solange Peters, MD, PhD,Joshua K. Sabari, MD,Edward B. Garon, MD, MS,Marina Chiara Garassino, MD A panel of thoracic medical oncologists discuss the first-line treatment options for patients with EGFR-mutant advanced non–small cell lung cancer.

A Role for Biomarkers in Selecting Appropriate Patients for ADCs in NSCLC
ByBenjamin P. Levy, MD,Solange Peters, MD, PhD,Joshua K. Sabari, MD,Edward B. Garon, MD, MS,Marina Chiara Garassino, MD Expert perspectives on the role of clinical biomarkers in selecting appropriate patients for antibody-drug conjugates in non–small cell lung cancer.

TROPION-Lung04: Dato-DXd Plus Immunotherapy in Advanced NSCLC
ByBenjamin P. Levy, MD,Solange Peters, MD, PhD,Joshua K. Sabari, MD,Edward B. Garon, MD, MS,Marina Chiara Garassino, MD Joshua K. Sabari, MD, reviews data from the TROPION-Lung04 study, and the panel offers key takeaways on Dato-DXd and immunotherapy in advanced NSCLC.

Benjamin Philip Levy, MD, discusses the evolution of antibody-drug conjugates in non-small cell lung cancer following updated data to be read out for this treatment population throughout 2023.

Closing Thoughts on Evolving Antibody-Drug Conjugate Landscape
ByBenjamin P. Levy, MD,Michal F. Segal, RN,Benjamin Leon Musher, MD,Rasheda Persinger, MSN, AGNP-C, AOCNP,Kevin Kalinsky, MD, MS,Kayla Freeman, DNP, APRN, FNP-C The expert panel concludes the program with key takeaways and closing thoughts on the evolving antibody-drug conjugate space.

EVOKE-02: Sacituzumab Govitecan Plus Pembrolizumab in Advanced NSCLC
ByBenjamin P. Levy, MD,Solange Peters, MD, PhD,Joshua K. Sabari, MD,Edward B. Garon, MD, MS,Marina Chiara Garassino, MD Edward B. Garon, MD, MS, reviews data from the EVOKE-02 study, and the panel offers their thoughts on antibody-drug conjugates for the treatment of advanced NSCLC.

Expert Perspectives on the Results of the TROPION-Lung01 Study in NSCLC
ByBenjamin P. Levy, MD,Solange Peters, MD, PhD,Joshua K. Sabari, MD,Edward B. Garon, MD, MS,Marina Chiara Garassino, MD The expert panel reviews the results from the TROPION-Lung01 study and discusses how the data can inform treatment decisions for patients with previously treated NSCLC.

Benjamin Philip Levy, MD, discusses the current landscape of emerging antibody-drug conjugates (ADCs) and their early activity in advanced lung cancer, the potential utility of oncogene-directed ADCs for patients with driver mutations, and more.

Educating Community Specialists on Evolving Treatment Landscape
ByBenjamin P. Levy, MD,Michal F. Segal, RN,Benjamin Leon Musher, MD,Rasheda Persinger, MSN, AGNP-C, AOCNP,Kevin Kalinsky, MD, MS,Kayla Freeman, DNP, APRN, FNP-C Experts in breast, lung, and gastric malignancies provide insights on multidisciplinary care in oncology and educating community specialists.

Future Outlook for Treating Breast and Lung Cancers
ByBenjamin P. Levy, MD,Michal F. Segal, RN,Benjamin Leon Musher, MD,Rasheda Persinger, MSN, AGNP-C, AOCNP,Kevin Kalinsky, MD, MS,Kayla Freeman, DNP, APRN, FNP-C Medical oncologists discuss prospects and challenges in the breast and lung cancer treatment landscapes.

TROPION-Lung01: Dato-DXd in Previously Treated Advanced NSCLC
ByBenjamin P. Levy, MD,Solange Peters, MD, PhD,Joshua K. Sabari, MD,Edward B. Garon, MD, MS,Marina Chiara Garassino, MD Solange Peters, MD, PhD, reviews key data from TROPION-Lung01 investigating datopotamab deruxtecan (Dato-DXd) in patients with previously treated advanced non–small cell lung cancer.

NSCLC: PD-L1 Expression and Treatment Decision-Making
ByBenjamin P. Levy, MD,Solange Peters, MD, PhD,Joshua K. Sabari, MD,Edward B. Garon, MD, MS,Marina Chiara Garassino, MD Clinical insights on how the level of PD-L1 expression informs treatment decisions for patients with non–small cell lung cancer.

Future Directions in Gastric Cancer Treatment
ByBenjamin P. Levy, MD,Michal F. Segal, RN,Benjamin Leon Musher, MD,Rasheda Persinger, MSN, AGNP-C, AOCNP,Kevin Kalinsky, MD, MS,Kayla Freeman, DNP, APRN, FNP-C Specialists in gastric cancer look to the future treatment landscape and review ongoing research in the disease space.

Treatment Considerations With TROP2-Targeted Therapy
ByBenjamin P. Levy, MD,Michal F. Segal, RN,Benjamin Leon Musher, MD,Rasheda Persinger, MSN, AGNP-C, AOCNP,Kevin Kalinsky, MD, MS,Kayla Freeman, DNP, APRN, FNP-C Clinical insights on best practices for treating patients with TROP2-targeted therapy.

The Role of CTLA-4 Inhibitors in NSCLC
ByBenjamin P. Levy, MD,Solange Peters, MD, PhD,Joshua K. Sabari, MD,Edward B. Garon, MD, MS,Marina Chiara Garassino, MD Experts on non–small cell lung cancer discuss the role of CTLA-4 inhibitors in the NSCLC treatment landscape.

First-Line Treatment Strategies for Advanced Non–Small Cell Lung Cancer
ByBenjamin P. Levy, MD,Solange Peters, MD, PhD,Joshua K. Sabari, MD,Edward B. Garon, MD, MS,Marina Chiara Garassino, MD A panel of thoracic medical oncologists provide an overview of first-line treatment strategies for advanced non–small cell lung cancer (NSCLC).

Benjamin Philip Levy, MD, discusses the ongoing development of the TROP-2 directed antibody-drug conjugates sacituzumab govitecan-hziy and datopotamab deruxtecan in non–small cell lung cancer, their different toxicity profiles, as well as the potential categorization of emerging ADCs as onco-directed therapies in this patient population.

Benjamin Philip Levy, MD, discusses antibody-drug conjugates under investigation in patients with non–small cell lung cancer.

TROP2-Targeting Antibody-Drug Conjugates
ByBenjamin P. Levy, MD,Michal F. Segal, RN,Benjamin Leon Musher, MD,Rasheda Persinger, MSN, AGNP-C, AOCNP,Kevin Kalinsky, MD, MS,Kayla Freeman, DNP, APRN, FNP-C The expert panel discusses TROP2 as a target for patients with cancer who are receiving antibody-drug conjugates.

Approved Antibody-Drug Conjugates in Breast, Lung, and GI Malignancies
ByBenjamin P. Levy, MD,Michal F. Segal, RN,Benjamin Leon Musher, MD,Rasheda Persinger, MSN, AGNP-C, AOCNP,Kevin Kalinsky, MD, MS,Kayla Freeman, DNP, APRN, FNP-C A review of antibody-drug conjugates approved for treatment of patients with breast, lung, or gastrointestinal cancers.

The mitigation and management of toxicities is a key component of treating patients with biliary tract cancers with targeted therapies.

Managing T-DXd Toxicities in Gastric Cancer
ByBenjamin P. Levy, MD,Michal F. Segal, RN,Benjamin Leon Musher, MD,Rasheda Persinger, MSN, AGNP-C, AOCNP,Kevin Kalinsky, MD, MS,Kayla Freeman, DNP, APRN, FNP-C Insights on managing antibody-drug conjugate toxicities for patients with gastric cancer.

Gastric Cancer Treatment: T-DXd
ByBenjamin P. Levy, MD,Michal F. Segal, RN,Benjamin Leon Musher, MD,Rasheda Persinger, MSN, AGNP-C, AOCNP,Kevin Kalinsky, MD, MS,Kayla Freeman, DNP, APRN, FNP-C A GI medical oncologist discusses the role of trastuzumab deruxtecan in the gastric cancer treatment space.

Expert oncologist Benjamin Levy, MD, shares data from the LIBRETTO-431 trial comparing selpercatinib to chemotherapy plus pembrolizumab in RET fusion-positive NSCLC following ESMO 2023.

Management of ADC Toxicities in Lung Cancer
ByBenjamin P. Levy, MD,Michal F. Segal, RN,Benjamin Leon Musher, MD,Rasheda Persinger, MSN, AGNP-C, AOCNP,Kevin Kalinsky, MD, MS,Kayla Freeman, DNP, APRN, FNP-C A nurse practitioner provides insights on toxicity management strategies for patients with lung cancer who are receiving antibody-drug conjugates.

Antibody-Drug Conjugates in Lung Cancer
ByBenjamin P. Levy, MD,Michal F. Segal, RN,Benjamin Leon Musher, MD,Rasheda Persinger, MSN, AGNP-C, AOCNP,Kevin Kalinsky, MD, MS,Kayla Freeman, DNP, APRN, FNP-C A medical oncologist reviews the antibody-drug conjugate landscape in lung cancer.

Toxicity Management for T-DM1 and T-DXd in Breast Cancer
ByBenjamin P. Levy, MD,Michal F. Segal, RN,Benjamin Leon Musher, MD,Rasheda Persinger, MSN, AGNP-C, AOCNP,Kevin Kalinsky, MD, MS,Kayla Freeman, DNP, APRN, FNP-C Specialists in breast cancer review toxicity management practices for T-DM1 and trastuzumab deruxtecan [T-DXd].

Antibody-Drug Conjugates in Breast Cancer
ByBenjamin P. Levy, MD,Michal F. Segal, RN,Benjamin Leon Musher, MD,Rasheda Persinger, MSN, AGNP-C, AOCNP,Kevin Kalinsky, MD, MS,Kayla Freeman, DNP, APRN, FNP-C A breast medical oncologist provides insights on antibody-drug conjugates in the breast cancer space and discusses ongoing research.

Best Practices for Patient Education Surrounding Cancer Treatment
ByBenjamin P. Levy, MD,Michal F. Segal, RN,Benjamin Leon Musher, MD,Rasheda Persinger, MSN, AGNP-C, AOCNP,Kevin Kalinsky, MD, MS,Kayla Freeman, DNP, APRN, FNP-C The expert panel has a comprehensive discussion about best practices for patient education and the barriers to effective testing.

Molecular Testing Considerations in Cancer Treatment
ByBenjamin P. Levy, MD,Michal F. Segal, RN,Benjamin Leon Musher, MD,Rasheda Persinger, MSN, AGNP-C, AOCNP,Kevin Kalinsky, MD, MS,Kayla Freeman, DNP, APRN, FNP-C Medical oncologists review the complexities of molecular testing, including tissue exhaustion, and discuss management approaches.