Opinion|Videos|February 6, 2026
CNS Metastases in EGFR+ NSCLC: Data for Amivantamab Plus Lazertinib
The FDA-approved combination of amivantamab and lazertinib transforms frontline treatment for EGFR-mutated lung cancer, enhancing patient outcomes and convenience.
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Episodes in this series
Joshua K. Sabari, MD, and Alexander I. Spira, MD, PhD, FACP, FASCO, Sabari and Spira focus on treatment challenges in patients with EGFR-mutated NSCLC and brain metastases. They review available data on intracranial activity with amivantamab plus lazertinib. The discussion highlights the importance of CNS control when selecting frontline targeted strategies.
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