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Opinion|Videos|February 6, 2026

CNS Metastases in EGFR+ NSCLC: Data for Amivantamab Plus Lazertinib

Author(s)Joshua K. Sabari, MD, Alexander I. Spira, MD, PhD, FACP, FASCO

The FDA-approved combination of amivantamab and lazertinib transforms frontline treatment for EGFR-mutated lung cancer, enhancing patient outcomes and convenience.

Episodes in this series

2 experts are featured in this series.

EP. 1 Current Frontline Treatment Approaches in EGFR+ Advanced NSCLC

2 experts are featured in this series.

EP. 2 The Role of Amivantamab Plus Lazertinib in EGFR+ NSCLC

2 experts are featured in this series.

EP. 3 CNS Metastases in EGFR+ NSCLC: Data for Amivantamab Plus Lazertinib

2 experts are featured in this series.

EP. 4 Safety Considerations for Frontline Regimens in EGFR+ NSCLC

Joshua K. Sabari, MD, and Alexander I. Spira, MD, PhD, FACP, FASCO, Sabari and Spira focus on treatment challenges in patients with EGFR-mutated NSCLC and brain metastases. They review available data on intracranial activity with amivantamab plus lazertinib. The discussion highlights the importance of CNS control when selecting frontline targeted strategies.

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