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Opinion|Videos|January 30, 2026

Current Frontline Treatment Approaches in EGFR+ Advanced NSCLC

Author(s)Joshua K. Sabari, MD, Alexander I. Spira, MD, PhD, FACP, FASCO

Experts explore the evolving standards of care for EGFR-mutated advanced NSCLC, highlighting therapy selection and innovative combination strategies.

Episodes in this series

2 experts are featured in this series.

EP. 1 Current Frontline Treatment Approaches in EGFR+ Advanced NSCLC

2 experts are featured in this series.

EP. 2 The Role of Amivantamab Plus Lazertinib in EGFR+ NSCLC

Joshua K. Sabari, MD, and Alexander I. Spira, MD, PhD, FACP, FASCO, review current standards of care for patients with EGFR-mutated advanced non–small cell lung cancer (NSCLC). They discuss how mutation subtype, disease burden, and patient-specific factors influence frontline therapy selection. The conversation also frames how newer combination strategies are being integrated alongside established EGFR TKIs.

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