
Opinion|Videos|February 13, 2026
How Subcutaneous Amivantamab Could Affect Clinical Management of EGFR+ NSCLC
Subcutaneous amivantamab offers significant advantages over IV administration, including reduced infusion reactions and quicker patient turnover in clinics.
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Episodes in this series

Joshua K. Sabari, MD, and Alexander I. Spira, MD, PhD, FACP, FASCO, discuss the potential impact of a subcutaneous formulation of amivantamab on patient care. They explore how administration route may influence clinic workflow, patient convenience, and treatment experience. Broader implications for access and adherence are also considered.
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David VanderWeele, MD, PhD, reviews where lutetium Lu 177 vipivotide tetraxetan fits across metastatic prostate cancer, how to select and manage patients, and the new radionuclides, targeting molecules, and antigens under investigation.

Longer follow-up of CAPItello-281 showed capivasertib plus abiraterone extended survival in PTEN-deficient hormone-sensitive prostate cancer.

Joshua J. Meeks, MD, PhD, explains how enfortumab vedotin plus pembrolizumab is reshaping organ preservation in MIBC.

Katie S. Murray, DO, discusses how efficacy, toxicity, patient preferences, and treatment logistics guide BCG-unresponsive NMIBC care.

Vignesh T. Packiam, MD, reviews why improved BCG outcomes support its first-line use, with gemcitabine/docetaxel as a BCG-sparing option.
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