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Opinion|Videos|February 13, 2026

Exploring Targeted Strategies in Early-Stage EGFR+ NSCLC

Author(s)Joshua K. Sabari, MD, Alexander I. Spira, MD, PhD, FACP, FASCO

Subcutaneous amivantamab offers significant advantages over IV administration, including reduced infusion reactions and quicker patient turnover in clinics.

Episodes in this series

2 experts are featured in this series.

EP. 1 Current Frontline Treatment Approaches in EGFR+ Advanced NSCLC

2 experts are featured in this series.

EP. 2 The Role of Amivantamab Plus Lazertinib in EGFR+ NSCLC

2 experts are featured in this series.

EP. 3 CNS Metastases in EGFR+ NSCLC: Data for Amivantamab Plus Lazertinib

2 experts are featured in this series.

EP. 4 Safety Considerations for Frontline Regimens in EGFR+ NSCLC

2 experts are featured in this series.

EP. 5 How Subcutaneous Amivantamab Could Affect Clinical Management of EGFR+ NSCLC

2 experts are featured in this series.

EP. 6 Exploring Targeted Strategies in Early-Stage EGFR+ NSCLC

2 experts are featured in this series.

EP. 7 Ongoing Research to Watch in EGFR+ NSCLC

Joshua K. Sabari, MD, and Alexander I. Spira, MD, PhD, FACP, FASCO, turn to the evolving role of targeted therapy in earlier-stage EGFR-mutated NSCLC. They outline ongoing research evaluating EGFR-directed approaches in the adjuvant and perioperative settings. The discussion highlights how these strategies may shift treatment paradigms beyond metastatic disease.

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