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Opinion|Videos|January 30, 2026

The Role of Amivantamab Plus Lazertinib in EGFR+ NSCLC

Author(s)Joshua K. Sabari, MD, Alexander I. Spira, MD, PhD, FACP, FASCO

The FDA approval of amivantamab and lazertinib transforms frontline treatment for EGFR-mutated lung cancer, enhancing patient outcomes and convenience.

Episodes in this series

2 experts are featured in this series.

EP. 1 Current Frontline Treatment Approaches in EGFR+ Advanced NSCLC

2 experts are featured in this series.

EP. 2 The Role of Amivantamab Plus Lazertinib in EGFR+ NSCLC

Joshua K. Sabari, MD, and Alexander I. Spira, MD, PhD, FACP, FASCO, examine the rationale for combining amivantamab with lazertinib in EGFR-mutated NSCLC. They summarize key efficacy signals and how this regimen may compare with existing targeted monotherapy and combination approaches. Clinical considerations for incorporating the combination into practice are also discussed.

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