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Opinion|Videos|February 6, 2026

Safety Considerations for Frontline Regimens in EGFR+ NSCLC

Author(s)Joshua K. Sabari, MD, Alexander I. Spira, MD, PhD, FACP, FASCO

Explore the impact of CNS metastasis on prognosis in EGFR mutant lung cancer and the promising results from the MARIPOSA trial.

Episodes in this series

2 experts are featured in this series.

EP. 1 Current Frontline Treatment Approaches in EGFR+ Advanced NSCLC

2 experts are featured in this series.

EP. 2 The Role of Amivantamab Plus Lazertinib in EGFR+ NSCLC

2 experts are featured in this series.

EP. 3 CNS Metastases in EGFR+ NSCLC: Data for Amivantamab Plus Lazertinib

2 experts are featured in this series.

EP. 4 Safety Considerations for Frontline Regimens in EGFR+ NSCLC

Joshua K. Sabari, MD, and Alexander I. Spira, MD, PhD, FACP, FASCO, outline key safety profiles of frontline regimens used in EGFR-mutated NSCLC. They discuss common adverse events, monitoring strategies, and dose modification approaches. They also emphasize balancing efficacy with tolerability in long-term disease management.

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