Opinion|Videos|February 6, 2026

Safety Considerations for Frontline Regimens in EGFR+ NSCLC

Explore the impact of CNS metastasis on prognosis in EGFR mutant lung cancer and the promising results from the MARIPOSA trial.

Joshua K. Sabari, MD, and Alexander I. Spira, MD, PhD, FACP, FASCO, outline key safety profiles of frontline regimens used in EGFR-mutated NSCLC. They discuss common adverse events, monitoring strategies, and dose modification approaches. They also emphasize balancing efficacy with tolerability in long-term disease management.

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