Considerations for COVID-19 in MCL and CLL

EP: 1.Disease Overview: Mantle Cell Lymphoma

EP: 2.Factors for Consideration in Treatment Decision-making for MCL

EP: 3.Mantle Cell Lymphoma Maintenance Strategies

EP: 4.Second-line Therapies in MCL: Regimens With BTK Inhibitors and BCL-2 Targeting Therapies

EP: 5.BTK Inhibitors in Relapsed/Refractory MCL and Treatment Selection

EP: 6.CAR T-Cell Therapy in R/R MCL

EP: 7.Strategies for Sequencing and Combining Therapies in MCL

EP: 8.Advancements on the Horizon in Mantle Cell Lymphoma

EP: 9.Treatment Overview: Chronic Lymphocytic Leukemia

EP: 10.Acalabrutinib in CLL: Insights from the ELEVATE TN and ASCEND Trials

EP: 11.Zanubrutinib in CLL: The ALPINE Trial

EP: 12.Treatment Decision-making Among Second-generation BTKis in CLL

EP: 13.Updates from Patient-reported QOL and Matching-adjusted Indirect Treatment Comparisons (MAICs) Studies in CLL

EP: 14.Emerging Approaches in CLL

EP: 15.TRANSCEND CLL: CAR T-cell Therapy for CLL

EP: 16.The Potential Role of Venetoclax Combination Approaches in CLL

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EP: 17.Considerations for COVID-19 in MCL and CLL

EP: 18.Anti-CD20 Regimens and Triplet Therapies in CLL

EP: 19.Pirtobrutinib and Other Non-Covalent BTK Inhibitors in the Treatment of CLL

EP: 20.Closing Remarks on Upcoming Data and Future Perspectives in MCL and CLL

Anthony R. Mato, MD, MSCE: Callie, I want to jump into the COVID-19 pandemic. This is a topic that we are all very much aware of, unfortunately, and rather than get into a historical lesson about what we were doing 3 years ago, I want to talk about today. Based on the state of the pandemic, is there any limitation to the use of any of the targeted therapies or antibodies in your practice, or should we be changing our approach to patients with CLL [chronic lymphocytic leukemia] based on the current pandemic?

Catherine C. Coombs, MD: I do not recommend any change to my own practice, based on the availability of so many drugs to treat COVID-19 that we didn’t have before. I make sure all my patients are vaccinated fully. I do caution them that there may be lower efficacy of the vaccines when they’re on a BTK [Bruton tyrosine kinase] inhibitor, especially in the setting of anti-CD20s. However, I also offer all of them Evusheld [tixagevimab with cilgavimab], and I have been impressed with its tolerability. I’ve had very few breakthrough cases, and the ones I’ve had have been very mild. Is that [due to] the drug, is that [due to] the fact we’re now in the Omicron [variant] era, [with] Omicron itself [being] less severe, or both? Who knows? But I think things are a lot more manageable now. Even in the setting of COVID-19, we also have all these drugs we can offer patients. I don’t end up using a lot of Paxlovid [nirmatrelvir and ritonavir] due to the drug interactions, with the exception being my patients on watchful waiting. We also have a variety of monoclonal antibodies that have come through for treatment of symptomatic COVID-19, so I think we should offer our best therapies to our patients. I think we are doing quite well with the COVID-19 therapeutics, and the era is a lot different now than it was 2 years ago.

Anthony R. Mato, MD, MSCE: Thanks so much. Does anybody have anything to add that would be different than what Callie just said? I agree with her completely.

Transcript has been edited for clarity.