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Opinion|Videos|July 23, 2024

DELLphi-301: Platinum Chemotherapy Efficacy in SCLC Survival

Author(s)Ticiana A. Leal, MD, Anne Chiang, MD, Afshin Dowlati, MD

In a detailed analysis, key opinion leaders (KOLs) review the results of the DELLphi-301 Phase 2 clinical trial, assessing the efficacy of platinum-based chemotherapy in the treatment of small cell lung cancer (SCLC) and its impact on overall survival outcomes for patients enrolled in the study.

Episodes in this series

4 KOLs are featured in this series

EP. 1 Optimizing First-Line Therapy for Limited-Stage Small Cell Lung Cancer

4 KOLs are featured in this series

EP. 2 ADRIATIC Trial: Durvalumab, cCRT Timing, and Survival in LS-SCLC

4 KOLs are featured in this series

EP. 3 cCRT-to-Durvalumab Interval in Limited Stage LS-SCLC

4 KOLs are featured in this series

EP. 4 Examining 3-Year Update Data from the CASPIAN Trial

4 KOLs are featured in this series

EP. 5 Predictors of Immunotherapy Response in Limited and Extensive SCLC

4 KOLs are featured in this series

EP. 6 Overcoming Immunotherapy Resistance in Small Cell Lung Cancer

4 KOLs are featured in this series

EP. 7 Examining the use of PD-L1 and tTMB in the CASPIAN Trial

4 KOLs are featured in this series

EP. 8 Redefining SCLC: Molecular Subtypes and Blood Biomarkers Guide Therapy

A panel of 4 experts on lung cancer

EP. 9 Navigating Later-Line Therapy Sequencing in LS-SCLC Progression

A panel of 4 experts on lung cancer

EP. 10 DELLphi-301: Platinum Chemotherapy Efficacy in SCLC Survival

A panel of 4 experts on lung cancer

EP. 11 Reviewing Ideate-Lung02: Durable Responses in Advanced SCLC

A panel of 4 experts on lung cancer

EP. 12 Examining Key Data from DAREON-8

A panel of 4 experts on lung cancer

EP. 13 Closing Thoughts and Key Takeaways on Small Cell Lung Cancer

Video content above is prompted by the following questions:

DELLphi-301 Phase 2 Clinical Trial of Tarlatamab
- Please share your insights on the importance of ORR and DoR in patients with ES-SCLC who have relapsed or who are refractory to platinum-based chemotherapy.
- At the community practice level, does 90 days continue to mark platinum sensitivity status among patients with ES SCLC?
- What other factors contribute to the definition of treatment resistance in this patient subgroup?
- How clinically meaningful is a median OS of 14 months and a DoR of between 6 and 9 months in patients with relapsed or refractory ES SCLC?
- How do you weigh the risk-benefit ratio of treatment with tarlatamab in relapsed or refractory ES SCLC?
- To what degree might a Black Box warning on risk of CRS and ICANS impact ready adoption of this new therapy by community oncologists for their patients with progressive ES SCLC?
- Given that no fatal CRS or ICANS events were reported with the 10 mg dose and only one dose interruption was reported in Part 1 and 2 of the published Phase II study report, what is the potential to reduce patient monitoring time between bimonthly infusions of tarlatamab?

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