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Opinion|Videos|June 25, 2024

Optimizing First-Line Therapy for Limited-Stage Small Cell Lung Cancer

Author(s)Ticiana A. Leal, MD, Anne Chiang, MD, PhD, Yale School of Medicine Smilow Cancer Hospital, Afshin Dowlati, MD

Medical experts in small cell lung cancer convene to examine first-line treatments, ongoing clinical trials, and emerging therapies shaping the evolving treatment landscape.

Episodes in this series

4 KOLs are featured in this series

EP. 1 Optimizing First-Line Therapy for Limited-Stage Small Cell Lung Cancer

4 KOLs are featured in this series

EP. 2 ADRIATIC Trial: Durvalumab, cCRT Timing, and Survival in LS-SCLC

4 KOLs are featured in this series

EP. 3 cCRT-to-Durvalumab Interval in Limited Stage LS-SCLC

4 KOLs are featured in this series

EP. 4 Examining 3-Year Update Data from the CASPIAN Trial

4 KOLs are featured in this series

EP. 5 Predictors of Immunotherapy Response in Limited and Extensive SCLC

4 KOLs are featured in this series

EP. 6 Overcoming Immunotherapy Resistance in Small Cell Lung Cancer

4 KOLs are featured in this series

EP. 7 Examining the use of PD-L1 and tTMB in the CASPIAN Trial

4 KOLs are featured in this series

EP. 8 Redefining SCLC: Molecular Subtypes and Blood Biomarkers Guide Therapy

A panel of 4 experts on lung cancer

EP. 9 Navigating Later-Line Therapy Sequencing in LS-SCLC Progression

A panel of 4 experts on lung cancer

EP. 10 DELLphi-301: Platinum Chemotherapy Efficacy in SCLC Survival

A panel of 4 experts on lung cancer

EP. 11 Reviewing Ideate-Lung02: Durable Responses in Advanced SCLC

A panel of 4 experts on lung cancer

EP. 12 Examining Key Data from DAREON-8

A panel of 4 experts on lung cancer

EP. 13 Closing Thoughts and Key Takeaways on Small Cell Lung Cancer

Briefly explore the current landscape of first-line treatment for limited-stage small cell lung cancer:
1. What clinical factors influence or impact the initial diagnostic workup and management of patients with LS-SCLC?
2. To what degree is a multidisciplinary team approach adopted when developing a treatment plan for patients with SCLC?
3. With respect to limited-stage disease, which patients are most likely to benefit from surgery and does lobectomy remain the preferred procedure for stageI-IIA (T1-2,N0,M0) disease?
4. To what degree does pathologic mediastinal lymph node stage influence your treatment path?
Under what circumstances would surgery versus RT be a preferred approach for a patient with stage I-IIA SCLC?

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