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Opinion|Videos|July 30, 2024

Examining Key Data from DAREON-8

Author(s)Ticiana A. Leal, MD, Anne Chiang, MD, Afshin Dowlati, MD

Experts delve into the DAREON-8 Phase 1 clinical trial, assessing the potential impact of incorporating the study into the current treatment algorithm for small cell lung cancer (SCLC).

Episodes in this series

4 KOLs are featured in this series

EP. 1 Optimizing First-Line Therapy for Limited-Stage Small Cell Lung Cancer

4 KOLs are featured in this series

EP. 2 ADRIATIC Trial: Durvalumab, cCRT Timing, and Survival in LS-SCLC

4 KOLs are featured in this series

EP. 3 cCRT-to-Durvalumab Interval in Limited Stage LS-SCLC

4 KOLs are featured in this series

EP. 4 Examining 3-Year Update Data from the CASPIAN Trial

4 KOLs are featured in this series

EP. 5 Predictors of Immunotherapy Response in Limited and Extensive SCLC

4 KOLs are featured in this series

EP. 6 Overcoming Immunotherapy Resistance in Small Cell Lung Cancer

4 KOLs are featured in this series

EP. 7 Examining the use of PD-L1 and tTMB in the CASPIAN Trial

4 KOLs are featured in this series

EP. 8 Redefining SCLC: Molecular Subtypes and Blood Biomarkers Guide Therapy

A panel of 4 experts on lung cancer

EP. 9 Navigating Later-Line Therapy Sequencing in LS-SCLC Progression

A panel of 4 experts on lung cancer

EP. 10 DELLphi-301: Platinum Chemotherapy Efficacy in SCLC Survival

A panel of 4 experts on lung cancer

EP. 11 Reviewing Ideate-Lung02: Durable Responses in Advanced SCLC

A panel of 4 experts on lung cancer

EP. 12 Examining Key Data from DAREON-8

A panel of 4 experts on lung cancer

EP. 13 Closing Thoughts and Key Takeaways on Small Cell Lung Cancer

Video content above is prompted by the following questions:

DAREON-8: Phase 1 Clinical Trial of Combination Therapy with BI 764532, a DLL3 Targeting T-Cell Engager
1. Please share your opinions of the therapeutic potential of Bl 764532, an lgG-like T-cell engager, for its ability to induce selective T-cell mediated tumor cell lysis when added to SOC (carboplatin + etoposide + atezolizumab) for previously untreated patients with ES-SCLC:
2. Is a commercial molecular assay currently available to identify the presence of the delta-like ligand 3 notch receptor in patients with SCLC?
3. Are you encouraged by an overall response rate of 28% and a 54% disease control rate in the Phase I trial?
4. For which line of therapy do you envision BI 764532, if approved?
5. Based on the exclusion criteria for the dose escalation trial, are you concerned that this agent may be associated with cardiovascular, cerebrovascular, and/or immunosuppressive TRAEs?

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