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Opinion|Videos|July 30, 2024

Reviewing Ideate-Lung02: Durable Responses in Advanced SCLC

Author(s)Ticiana A. Leal, MD, Anne Chiang, MD, Afshin Dowlati, MD

Medical experts review the Ideate-Lung02 phase 3 clinical trial, exploring the potential for ifinatamab to elicit durable responses in patients with advanced small cell lung cancer (SCLC), and discussing the implications of these findings for the future treatment landscape of SCLC.

Episodes in this series

4 KOLs are featured in this series

EP. 1 Optimizing First-Line Therapy for Limited-Stage Small Cell Lung Cancer

4 KOLs are featured in this series

EP. 2 ADRIATIC Trial: Durvalumab, cCRT Timing, and Survival in LS-SCLC

4 KOLs are featured in this series

EP. 3 cCRT-to-Durvalumab Interval in Limited Stage LS-SCLC

4 KOLs are featured in this series

EP. 4 Examining 3-Year Update Data from the CASPIAN Trial

4 KOLs are featured in this series

EP. 5 Predictors of Immunotherapy Response in Limited and Extensive SCLC

4 KOLs are featured in this series

EP. 6 Overcoming Immunotherapy Resistance in Small Cell Lung Cancer

4 KOLs are featured in this series

EP. 7 Examining the use of PD-L1 and tTMB in the CASPIAN Trial

4 KOLs are featured in this series

EP. 8 Redefining SCLC: Molecular Subtypes and Blood Biomarkers Guide Therapy

A panel of 4 experts on lung cancer

EP. 9 Navigating Later-Line Therapy Sequencing in LS-SCLC Progression

A panel of 4 experts on lung cancer

EP. 10 DELLphi-301: Platinum Chemotherapy Efficacy in SCLC Survival

A panel of 4 experts on lung cancer

EP. 11 Reviewing Ideate-Lung02: Durable Responses in Advanced SCLC

A panel of 4 experts on lung cancer

EP. 12 Examining Key Data from DAREON-8

A panel of 4 experts on lung cancer

EP. 13 Closing Thoughts and Key Takeaways on Small Cell Lung Cancer

Video content above is prompted by the following questions:

B. Ideate-Lung02: Phase 3 Clinical Trial of Ifinatamab Deruxtecan vs TPC in Relapsed ES-SCL [TPS8126]
1. Please share your perceptions of the potential for durable response to ifinatamab, a B7-H3-directed ADC in patients with previously treated, relapsed SCLC.
2. How encouraging is an ORR of 52.4%, a 5.9-month median DoR, and a 12.2-month
3. OS after a median 2 prior lines of therapy as reported in the Phase I/II trial?
4. Currently, can you assay B7-H3 to determine individual expression levels?
5. How does a treatment schedule of 12 mg/kg IV Q3W compare with that of:
6. amrubicin [(Calsed) aminoanthracycline]: 45mg/m2 IV Infusion QD x 3 days Q3W [Japan]
7. topotecan [(Hycamtin) topoisomerase inhibitor]: 1.5 mg/m2 IV infusion QD, Days 1-5 Q3W
8. lurbinectedin [(Zepzelca) alkylating agent]: 3.2 mg/m2IV infusion Q3W
What is the potential for immunogenicity with this ADC, and which treatment-related adverse events would most concern you?

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