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Opinion|Videos|July 23, 2024

Navigating Later-Line Therapy Sequencing in LS-SCLC Progression

Author(s)Ticiana A. Leal, MD, Anne Chiang, MD, Afshin Dowlati, MD

In a focused discussion, Anne Chiang, MD, PhD, explores the sequencing of later-line therapies for limited-stage small cell lung cancer (LS-SCLC), emphasizing key factors to consider when making treatment decisions for patients who have progressed on initial therapy.

Episodes in this series

4 KOLs are featured in this series

EP. 1 Optimizing First-Line Therapy for Limited-Stage Small Cell Lung Cancer

4 KOLs are featured in this series

EP. 2 ADRIATIC Trial: Durvalumab, cCRT Timing, and Survival in LS-SCLC

4 KOLs are featured in this series

EP. 3 cCRT-to-Durvalumab Interval in Limited Stage LS-SCLC

4 KOLs are featured in this series

EP. 4 Examining 3-Year Update Data from the CASPIAN Trial

4 KOLs are featured in this series

EP. 5 Predictors of Immunotherapy Response in Limited and Extensive SCLC

4 KOLs are featured in this series

EP. 6 Overcoming Immunotherapy Resistance in Small Cell Lung Cancer

4 KOLs are featured in this series

EP. 7 Examining the use of PD-L1 and tTMB in the CASPIAN Trial

4 KOLs are featured in this series

EP. 8 Redefining SCLC: Molecular Subtypes and Blood Biomarkers Guide Therapy

A panel of 4 experts on lung cancer

EP. 9 Navigating Later-Line Therapy Sequencing in LS-SCLC Progression

A panel of 4 experts on lung cancer

EP. 10 DELLphi-301: Platinum Chemotherapy Efficacy in SCLC Survival

A panel of 4 experts on lung cancer

EP. 11 Reviewing Ideate-Lung02: Durable Responses in Advanced SCLC

A panel of 4 experts on lung cancer

EP. 12 Examining Key Data from DAREON-8

A panel of 4 experts on lung cancer

EP. 13 Closing Thoughts and Key Takeaways on Small Cell Lung Cancer

Video content above is prompted by the following questions:

After frontline therapy in limited-stage small cell lung cancer (LS-SCLC), how do you determine the appropriate second-line and subsequent therapy?
- What patient-specific factors do you consider?
- Other than clinical trial enrollment, what would you consider for second-line treatment?
- Please briefly describe the SWOG umbrella protocol for ES-SCLC
Can we personalize treatment by identifying molecular subtypes that may be more responsive to certain therapies than others?
Please provide your insights on the potential for improved survival benefits with chemoimmunotherapy and consolidative thoracic radiotherapy in patients with ES-SCLC.
- What additional research should be conducted to further validate the use of CIT and cTRT in this patient population?
Please briefly comment on key updates in SCLC recently presented at ASCO 2024 and discuss how these findings may impact the overall treatment landscape.

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