Giredestrant vs Standard-of-Care Endocrine Therapy as Adjuvant Treatment for Patients with Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer: Results From the Global Phase III lidERA Breast Cancer Trial

This rapid readout highlights results from a global Phase III trial evaluating giredestrant as adjuvant therapy for estrogen receptor–positive, HER2-negative early breast cancer. The study demonstrated a clinically meaningful improvement in invasive disease-free survival compared with standard endocrine therapy, with a favorable and comparable safety profile.