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Opinion|Videos|April 25, 2025

MARIPOSA OS Data: Shaping Frontline Treatment in EGFR-Mutant NSCLC

Author(s)Helena A. Yu, MD, Linda Ahn, MSN, ANP-BC, AOCNP

Panelists discusses how the MARIPOSA trial demonstrated significant survival improvement with amivantamab plus lazertinib versus osimertinib alone in EGFR-mutant NSCLC, showing a hazard ratio of 0.75 and an expected 12-month survival benefit that could potentially change the natural history of this disease.

Episodes in this series

2 experts are featured in this series.

EP. 1 EGFR-Mutant NSCLC: Navigating an Increasingly Complex Treatment Landscape

2 experts are featured in this series.

EP. 2 MARIPOSA OS Data: Shaping Frontline Treatment in EGFR-Mutant NSCLC

2 experts are featured in this series.

EP. 3 Overall Survival as a Driver of 1L EGFRm NSCLC Treatment Selection

2 experts are featured in this series.

EP. 4 Understanding OS Through 2 Lenses: Patients and Providers in EGFRm NSCLC

2 experts are featured in this series.

EP. 5 Balancing Survival and Quality of Life in 1L EGFRm NSCLC Treatment Decisions

2 experts are featured in this series.

EP. 6 Translating OS Data Into Patient Conversations: Balancing Benefit and Burden

2 experts are featured in this series.

EP. 7 Balancing Clinical and Patient-Centered Factors in 1L EGFRm NSCLC Treatment

2 experts are featured in this series.

EP. 8 Impact of Disease Characteristics on 1L Treatment Decisions in EGFRm NSCLC

2 experts are featured in this series.

EP. 9 Weighing QoL and Toxicity in 1L EGFRm NSCLC Treatment Decisions

2 experts are featured in this series.

EP. 10 FLAURA2 Maintenance: Key Strategies for Treatment Optimization and Patient Monitoring

2 experts are featured in this series.

EP. 11 Evaluating Pemetrexed Exposure in FLAURA2: Key Findings and Treatment Implications

2 experts are featured in this series.

EP. 12 56-Year-Old Never-Smoker Female with High-Risk Metastatic EGFR-Mutant NSCLC Treated with the FLAURA2 Regimen

2 experts are featured in this series.

EP. 13 45-Year-Old Never-Smoker with Advanced EGFR-Mutant NSCLC and CNS Metastases Treated with the MARIPOSA Regimen

2 experts are featured in this series.

EP. 14 Looking Ahead: Unmet Needs and Future Directions in the Treatment of Advanced EGFR-Mutant NSCLC

Key Overall Survival Findings from MARIPOSA Trial

Main Discussion Topics:

Summary of recently presented MARIPOSA trial data at the European Lung Cancer Congress 2025
Discussion of overall survival (OS) benefit with amivantamab plus lazertinib vs osimertinib
Analysis of the clinical significance of the observed survival benefit

Key Points for Physicians:

MARIPOSA demonstrated a hazard ratio of 0.75 for OS
The OS curves between treatment groups continued to widen

Notable Insights:

A 12-month survival benefit is particularly significant in the context of metastatic EGFR-mutant NSCLC, where average survival is approximately 3 years.

Clinical Significance:

The MARIPOSA trial data represent a meaningful advance in treatment outcomes for metastatic EGFR-mutant NSCLC, potentially changing the natural history of the disease through combination therapy.

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