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Opinion|Videos|May 2, 2025

FLAURA2 Maintenance: Key Strategies for Treatment Optimization and Patient Monitoring

Author(s)Helena A. Yu, MD, Linda Ahn, MSN, ANP-BC, AOCNP

Panelists discuss how FLAURA2 maintenance therapy strategies involve monitoring patients for toxicities and implementing dose modifications or schedule adjustments to improve tolerability.

Episodes in this series

2 experts are featured in this series.

EP. 1 EGFR-Mutant NSCLC: Navigating an Increasingly Complex Treatment Landscape

2 experts are featured in this series.

EP. 2 MARIPOSA OS Data: Shaping Frontline Treatment in EGFR-Mutant NSCLC

2 experts are featured in this series.

EP. 3 Overall Survival as a Driver of 1L EGFRm NSCLC Treatment Selection

2 experts are featured in this series.

EP. 4 Understanding OS Through 2 Lenses: Patients and Providers in EGFRm NSCLC

2 experts are featured in this series.

EP. 5 Balancing Survival and Quality of Life in 1L EGFRm NSCLC Treatment Decisions

2 experts are featured in this series.

EP. 6 Translating OS Data Into Patient Conversations: Balancing Benefit and Burden

2 experts are featured in this series.

EP. 7 Balancing Clinical and Patient-Centered Factors in 1L EGFRm NSCLC Treatment

2 experts are featured in this series.

EP. 8 Impact of Disease Characteristics on 1L Treatment Decisions in EGFRm NSCLC

2 experts are featured in this series.

EP. 9 Weighing QoL and Toxicity in 1L EGFRm NSCLC Treatment Decisions

2 experts are featured in this series.

EP. 10 FLAURA2 Maintenance: Key Strategies for Treatment Optimization and Patient Monitoring

2 experts are featured in this series.

EP. 11 Evaluating Pemetrexed Exposure in FLAURA2: Key Findings and Treatment Implications

2 experts are featured in this series.

EP. 12 56-Year-Old Never-Smoker Female with High-Risk Metastatic EGFR-Mutant NSCLC Treated with the FLAURA2 Regimen

2 experts are featured in this series.

EP. 13 45-Year-Old Never-Smoker with Advanced EGFR-Mutant NSCLC and CNS Metastases Treated with the MARIPOSA Regimen

2 experts are featured in this series.

EP. 14 Looking Ahead: Unmet Needs and Future Directions in the Treatment of Advanced EGFR-Mutant NSCLC

Maintenance Therapy Strategies

Main Discussion Topics:

Considerations when implementing the FLAURA2 regimen
Management strategies for pemetrexed maintenance therapy
Monitoring patients during maintenance treatment

Key Points for Physicians:

FLAURA2 involves 4 cycles of carboplatin/pemetrexed followed by pemetrexed maintenance with osimertinib
Key toxicities to monitor include leg edema, mucositis, and renal dysfunction
Patient education and early intervention are crucial for managing toxicity

Notable Insights:

The flexibility to adjust maintenance therapy (dose reductions, treatment delays, or discontinuation) is an important aspect of optimizing the FLAURA2 regimen.

Clinical Significance:

Proactive monitoring and management of toxicities during maintenance therapy can help maintain treatment efficacy while preserving quality of life.

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