Balancing Survival and Quality of Life in 1L EGFRm NSCLC Treatment Decisions

Quality of Life vs Treatment Burden

Main Discussion Topics:

• Impact of different treatment regimens on patient quality of life
• Comparison of treatment burdens: oral therapy vs infusion-based regimens
• Consideration of financial costs and logistical challenges associated with different treatments

Key Points for Physicians:

• Treatment burden varies significantly: osimertinib is a daily pill with visits every 3 months, whereas combination therapies require infusions every 2 to 3 weeks
• More-intensive regimens involve greater “medicalization” of patient care
• Financial and logistical costs (travel, parking, childcare) must be considered

Notable Insights:

Patients fall on different ends of the spectrum regarding treatment preferences—some prioritize efficacy regardless of burden, and others prefer less- intensive regimens to maintain quality of life.

Clinical Significance:

The treatment decision ultimately depends on aligning therapy choice with individual patient values, circumstances, and priorities related to efficacy, quality of life, and treatment burden.