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Opinion|Videos|July 3, 2024

The EMBARK trial investigating enzalutamide in NM CSPC

Author(s)Stephen J. Freedland, MD, Eleni Efstathiou, MD, PhD

Prostate cancer experts analyze the EMBARK trial, emphasizing the potential impact of an androgen receptor inhibitor in the treatment of non-metastatic castration-sensitive prostate cancer.

Episodes in this series

2 KOLs are featured in this panel.

EP. 1 Testing Principes and Benefits of Early Intervention in Castration-Sensitive Prostate Cancer

2 KOLs are featured in this panel.

EP. 2 Risk Stratification and Prognostic Markers in castration-sensitive prostate cancer

2 KOLs are featured in this panel.

EP. 3 Evolving Treatment Paradigm and NCCN Guideline Updates

2 KOLs are featured in this panel.

EP. 4 The EMBARK trial investigating enzalutamide in NM CSPC

2 KOLs are featured in this panel.

EP. 5 The Role of PSA Doubling Time in Risk Assessment

2 KOLs are featured in this panel.

EP. 6 Patient Case 1: Non-Metastatic CSPC with Rapidly Doubling PSA

Stephen J. Freedland, MD, and Eleni Efstathiou, MD, PhD, experts on prostate cancer

EP. 7 Patient Case 2: Metastatic CSPC

Stephen J. Freedland, MD, and Eleni Efstathiou, MD, PhD, experts on prostate cancer

EP. 8 Final Thoughts on CSPC

Dr. Efstathiou asks Dr. Freedland: Enzalutamide is currently the only androgen receptor inhibitor approved for non-metastatic CSPC. Can you summarize the key data from the EMBARK trial supporting its use in this setting?
1. Please comment of the high risk study population evaluated in the EMBARK trial
2. What were the primary endpoints and efficacy findings from the EMBARK trial? Please also comment on your impressions of the monotherapy arm.
3. What are your impressions of the safety data from EMBARK?

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