Integrated Geriatric Assessment Optimizes Care for Older Adults with Cancer
May 13th 2020Integration of a comprehensive geriatric assessment with geriatrician-led management care improved health-related quality of life, unplanned hospital admissions, and treatment discontinuation among older adults undergoing systemic therapy for their cancer.
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Maintenance Therapy with Olaparib Extends Survival in Relapsed, BRCA+ Ovarian Cancer
May 13th 2020Treatment with olaparib in the maintenance setting extended overall survival by 12.9 months in women with platinum-sensitive relapsed ovarian cancer with BRCA1/2 mutations, compared with placebo, according to randomized phase 3 trial results presented during a 2020 ASCO Virtual Scientific Program press briefing.
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All Stakeholders Are Responsible for Genetic Testing
March 7th 2020Physicians should “get out there and test early and often,” to align with a potential new paradigm for genetic testing that allows anyone on the treatment team to identify and test individuals, with the specialist ultimately providing risk management, according to Kevin S. Hughes, MD, FACS.
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T-DXd Shows Potential to Establish New Standard of Care in Advanced HER2+ Breast Cancer
December 11th 2019Trastuzumab deruxtecan (T-DXd; DS-8201) induced a confirmed objective response rate of almost 61% and a durable benefit in heavily pretreated patients with advanced HER2-positive breast cancer.
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Chemo-Free Combo Significantly Improves PFS in Previously Untreated CLL
June 4th 2019The addition of venetoclax to obinutuzumab reduced the risk for disease worsening or death by 65% compared with obinutuzumab plus chlorambucil in patients with previously untreated chronic lymphocytic leukemia.
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Frontline Pembrolizumab Induces Comparable OS, Fewer AEs in Advanced GEJ Cancer
June 1st 2019Frontline pembrolizumab demonstrated non-inferior overall survival compared with standard chemotherapy among patients with PD-L1–positive, HER2-negative, advanced gastric or gastroesophageal junction cancer.
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Individualized Dosing Reduces Niraparib-Related TEAEs in Ovarian Cancer Maintenance
March 17th 2019Adverse events decreased among patients with high-risk ovarian cancer who received a 200- or 300-mg individualized starting dose of niraparib, based upon baseline bodyweight and platelet count, compared with a 300-mg fixed starting dose.
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Repeat Use of PARP Inhibitors Could Be Effective Strategy in Ovarian Cancer
March 17th 2019Prior exposure to PARP inhibitor treatment may not lead to resistance in future use with these agents in women with recurrent epithelial ovarian cancer, suggesting that repeat use could become more common.
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Maintenance Niraparib Extends PFS Without Symptoms, Toxicities in Recurrent Ovarian Cancer
March 17th 2019Patients with recurrent ovarian cancer who received niraparib maintenance therapy experienced more progression-free time without experiencing symptoms or toxicity compared with placebo; the benefit was 4-fold for those with germline (g) BRCA-mutated disease and 2-fold for non-gBRCA-mutated ovarian cancer.
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Awareness Critical for Identifying irAEs Early in Breast Cancer
March 10th 2019With tremendous advances and the accelerated approval of atezolizumab plus nab-paclitaxel for patients with unresectable locally advanced or metastatic PD-L1–positive triple-negative breast cancer, provider education in identifying associated toxicities from checkpoint inhibitor therapy is critical.
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Addition of Alpelisib Prolongs PFS in PIK3CA-Mutant HR+, HER2- Advanced Breast Cancer Subgroups
March 9th 2019The previously demonstrated progression-free survival benefit from the addition of alpelisib to fulvestrant appeared consistent among subgroups of patients with hormone receptor–positive/HER2-negative advanced breast cancer who have a PIK3CA mutation.
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Study Validates Speed, Accuracy of Liquid Biopsies Identifying NSCLC Biomarkers
February 28th 2019A liquid biopsy test detected all of the guideline-recommended biomarkers in newly diagnosed patients with metastatic non–small cell lung cancer at a similar rate but faster turnaround time to that of tissue genotyping.
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Hormonal Agents Induce Improved OS in African Americans With Chemo-Naive mCRPC
February 12th 2019African-American men with metastatic castration-resistant prostate cancer treated with novel hormonal therapies—namely abiraterone acetate or enzalutamide—lived 20% longer than their Caucasian counterparts.
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FDA Delays Decision on Frontline Pembrolizumab sBLA in NSCLC
December 21st 2018The FDA has extended the review period for a supplemental biologics license application for single-agent pembrolizumab for the frontline treatment of patients with locally advanced or metastatic nonsquamous or squamous non–small cell lung cancer with a PD-L1 expression level of ≥1% and no EGFR or ALK genomic tumor aberrations.
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FDA Grants Atezolizumab Regimen Priority Review for Frontline SCLC
December 5th 2018The FDA has granted a priority review designation to a supplemental biologics license application for atezolizumab for use in combination with carboplatin and etoposide for the frontline treatment of patients with extensive-stage small cell lung cancer.
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New Prediction Model Improves Personalized Insight Into MDS Survival
December 3rd 2018An approach using machine learning to analyze genomic and clinical data from patients with myelodysplastic syndromes could replace the gold standard of predicting how long patients may live with the disease.
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Beat AML Trial Proves Feasibility of Rapid Treatment Assignment Following Diagnosis
December 3rd 2018Initial findings from the Beat AML study showed that rapid genetic testing in patients with AML was feasible and helpful, and that a precision medicine approach is possible for these patients, who must be treated urgently given the disease’s rapid progression.
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First HCT Following CAR T-Cell Therapy Reduces Risk for ALL Relapse
December 2nd 2018Receiving a stem cell transplant for the first time following CD19 CAR T-cell therapy induced a reduction in the risk for acute lymphoblastic leukemia (ALL) recurrence, according to a retrospective analysis of the phase I/II PLAT-02 study.
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