Matthew T. Campbell, MD, MS, assistant professor in the Department of Genitourinary Medical Oncology of the Division of Cancer Medicine at The University of Texas MD Anderson Cancer Center, discusses the expanding role of cabozantinib (Cabometyx) in renal cell carcinoma (RCC). 

In clear cell RCC, cabozantinib is an active agent, says Campbell. 

Additionally, the drug has demonstrated benefit for patients with subtypes of non–clear cell RCC, such as papillary RCC, Campbell adds. The ongoing CABOSUN Ii trial (NCT03541902) is evaluating cabozantinib vs sunitinib (Sutent) in patients with metastatic variant histology RCC. 

Findings from the phase 3 METEOR trial demonstrated an improved objective response rate (ORR), median progression-free survival (PFS), and median overall survival (OS) with cabozantinib compared with everolimus (Afinitor) in patients with advanced RCC, Campbell explains. 

Furthermore, the phase 3 CheckMate-9ER trial demonstrated improved ORR, PFS, and OS with cabozantinib plus nivolumab (Opdivo) compared with sunitinib as frontline therapy for patients with advanced or metastatic RCC. 

In light of these positive findings, questions regarding sequencing with cabozantinib/nivolumab and long-term therapeutic strategies will need to be addressed, concludes Campbell.

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Matthew T. Campbell, MD, MS, discusses the expanding role of cabozantinib in renal cell carcinoma.  



Dr. Campbell on the Expanding Role of Cabozantinib in RCC  

Matthew T. Campbell, MD, MS, assistant professor in the Department of Genitourinary Medical Oncology of Division of Cancer Medicine at The University of Texas MD Anderson Cancer Center, shares ways to prevent the spread of coronavirus 2019 (COVID-19).

Try to avoid busy environments and work remotely if possible, Campbell suggests. Practicing good hand hygiene is a vital component of preventing the spread of infection, and it involves washing hands for 20 seconds with soap and water. Campbell suggests singing “Happy Birthday” twice to ensure hands have been washed for the appropriate amount of time. Pay extra attention to thumbs and wrists, which are areas people commonly miss. Furthermore, avoid visiting sick friends and relatives, adds Campbell.

Many patients with cancer have upper respiratory symptoms related to their cancer or other infections that are not COVID-19. Campbell hopes that testing capacity will increase in the United States so better control of COVID-19 can be achieved.

Matthew T. Campbell, MD, MS, shares ways to prevent the spread of coronavirus 2019.

Matthew T. Campbell, MD, MS

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Dr. Campbell on the Expanding Role of Cabozantinib in RCC

Dr. Campbell on Precautions for Preventing Spread of COVID-19