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Therapeutic options for pretreated HER2-positive breast cancer now include tucatinib (Tukysa) as part of a triplet regimen with a tolerable safety profile that promises improved quality of life.

The degree to which nature and nurture affect disease has long been debated in medicine, and it is an issue that esteemed breast cancer researcher and medical oncologist Joyce A. O’Shaughnessy, MD, has been working to unravel for her patients throughout a career that spans more than 30 years.

Tucatinib has been approved in Switzerland for use in combination with trastuzumab and capecitabine for patients with previously treated metastatic HER2-positive breast cancer.











Erika P. Hamilton, MD, discusses the evolution of treatment in HER2-positive breast cancer.

Trastuzumab emtansine has been approved in the UK for the adjuvant treatment of patients with HER2-positive early breast cancer.

Katherine D. Crew, MD, MS, discusses recent advances made in HER2-positive breast cancer treatment.

Sara M. Tolaney, MD, MPH, discusses sequencing strategies in metastatic HER2-positive breast cancer.

Anne Favret, MD, discusses the evolution of treatment in HER2-positive breast cancer.

Global access to neratinib has increased with the drug now being made commercially available in Singapore.































































